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BAAT抗體,Rabbit Polyclonal BAAT Antibody
  • BAAT抗體,Rabbit Polyclonal BAAT Antibody
  • BAAT抗體,Rabbit Polyclonal BAAT Antibody
  • BAAT抗體,Rabbit Polyclonal BAAT Antibody

BAAT抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BAAT抗體英文名稱:Rabbit Polyclonal BAAT Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3913 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): BAAT
2025-05-14 BAAT抗體 Rabbit Polyclonal BAAT Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3913 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBAT; BACAT
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human BAAT
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: P08061(BAAT Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08061(BAAT Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08061(BAAT Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于BAAT(Bile Acid-CoA: Amino Acid N-Acyltransferase)抗體的3篇示例參考文獻(xiàn)(內(nèi)容為模擬,建議通過學(xué)術(shù)數(shù)據(jù)庫驗(yàn)證):

1. **文獻(xiàn)名稱**:*"Immunolocalization and functional characterization of BAAT in human liver tissue"*

**作者**:Heubi, J.E., et al.

**摘要**:通過BAAT特異性抗體檢測人類肝臟中BAAT的分布,發(fā)現(xiàn)其在肝細(xì)胞胞質(zhì)中高表達(dá),研究證實(shí)BAAT缺失會導(dǎo)致膽汁酸結(jié)合異常,與遺傳性膽汁酸合成障礙相關(guān)。

2. **文獻(xiàn)名稱**:*"Development of a monoclonal antibody against BAAT for diagnostic applications in cholestatic liver disease"*

**作者**:Sundaram, S.S., et al.

**摘要**:報(bào)道一種高特異性BAAT單克隆抗體的開發(fā),用于ELISA檢測血清BAAT水平,發(fā)現(xiàn)其在原發(fā)性膽汁性膽管炎患者中顯著降低,提示其作為潛在生物標(biāo)志物的價(jià)值。

3. **文獻(xiàn)名稱**:*"Role of BAAT in bile acid amidation: Insights from gene knockout models"*

**作者**:Setchell, K.D.R., et al.

**摘要**:利用BAAT抗體研究基因敲除小鼠模型,發(fā)現(xiàn)BAAT缺失導(dǎo)致未結(jié)合膽汁酸積累,引發(fā)肝損傷和脂質(zhì)吸收障礙,闡明了其在膽汁酸代謝中的核心作用。

4. **文獻(xiàn)名稱**:*"Antibody-based detection of BAAT mutations in metabolic disorders"*

**作者**:Falany, C.N., et al.

**摘要**:通過BAAT抗體結(jié)合Western blot技術(shù),分析患者肝臟樣本中BAAT蛋白表達(dá)異常,揭示了特定突變導(dǎo)致酶活性喪失的分子機(jī)制。

**注**:以上為模擬參考文獻(xiàn),實(shí)際研究需通過PubMed、Google Scholar等平臺檢索關(guān)鍵詞(如“BAAT antibody”“bile acid amidation”)獲取真實(shí)文獻(xiàn)。

       

背景信息

BAAT (Bile Acid-CoA: Amino Acid N-Acyltransferase) is a critical enzyme in bile acid metabolism, responsible for catalyzing the conjugation of bile acids with amino acids (primarily glycine or taurine) in the liver. This process produces conjugated bile acids, which are essential for emulsifying dietary fats, facilitating lipid absorption, and regulating cholesterol homeostasis. Dysregulation of BAAT activity is linked to cholestatic liver diseases, metabolic disorders, and rare genetic conditions like familial hypercholanemia.

BAAT antibodies are immunological tools developed to detect, quantify, and study the expression, localization, and function of the BAAT protein in research and clinical contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to investigate BAAT’s role in liver pathophysiology, drug-induced hepatotoxicity, and bile acid synthesis disorders. Polyclonal and monoclonal BAAT antibodies enable researchers to explore tissue-specific expression patterns, protein-protein interactions, and mutations affecting enzyme activity.

Recent studies also utilize BAAT antibodies to validate gene-editing outcomes (e.g., CRISPR/Cas9) and assess therapeutic interventions targeting bile acid metabolism. Their application extends to diagnostic research for conditions like progressive familial intrahepatic cholestasis (PFIC), where BAAT mutations may contribute to disease progression. Overall, BAAT antibodies serve as pivotal reagents in advancing our understanding of hepatic function and metabolic diseases.

       
關(guān)鍵字: BAAT抗體;BAAT;BAAT Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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