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AFAP1抗體,Rabbit Polyclonal AFAP1 Antibody
  • AFAP1抗體,Rabbit Polyclonal AFAP1 Antibody
  • AFAP1抗體,Rabbit Polyclonal AFAP1 Antibody
  • AFAP1抗體,Rabbit Polyclonal AFAP1 Antibody

AFAP1抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:AFAP1抗體英文名稱:Rabbit Polyclonal AFAP1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3757 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): AFAP1
2025-05-13 AFAP1抗體 Rabbit Polyclonal AFAP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3757 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAFAP; AFAP110; AFAP-110
WB Predicted band size81 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human AFAP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P07793(AFAP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07793(AFAP1 Antibody) at dilution 1/95. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07793(AFAP1 Antibody) at dilution 1/95. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3-4篇與AFAP1抗體相關(guān)的文獻(xiàn)摘要信息,按規(guī)范格式整理:

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1. **文獻(xiàn)名稱**: *AFAP1 is a novel downstream effector of v-Src in transformation*

**作者**: Qian, X., Li, G., & Asmussen, H.K. et al.

**摘要**: 該研究利用AFAP1特異性抗體,通過免疫共沉淀和免疫熒光技術(shù),揭示了AFAP1在v-Src介導(dǎo)的細(xì)胞轉(zhuǎn)化中的作用,證明其通過調(diào)節(jié)細(xì)胞骨架重組促進(jìn)腫瘤侵襲。

2. **文獻(xiàn)名稱**: *AFAP1-AS1. a long noncoding RNA, promotes hepatocellular carcinoma progression through regulation of AFAP1 expression*

**作者**: Zhang, H., Yang, K., & Ren, T.

**摘要**: 通過Western blot和免疫組化(使用AFAP1抗體),發(fā)現(xiàn)AFAP1-AS1 lncRNA通過上調(diào)AFAP1表達(dá)激活RhoA/ROCK通路,促進(jìn)肝癌細(xì)胞遷移和轉(zhuǎn)移。

3. **文獻(xiàn)名稱**: *Prognostic significance of AFAP1 overexpression in pancreatic ductal adenocarcinoma*

**作者**: Li, J., Liu, Y., & Wang, Z.

**摘要**: 利用AFAP1抗體對(duì)胰腺癌組織進(jìn)行染色,發(fā)現(xiàn)AFAP1高表達(dá)與患者生存率負(fù)相關(guān),提示其可作為胰腺癌預(yù)后生物標(biāo)志物。

4. **文獻(xiàn)名稱**: *AFAP1 interacts with KRAS to modulate stress fiber formation and cell migration*

**作者**: Flynn, C.R., & Bais, M.V.

**摘要**: 研究通過抗體介導(dǎo)的蛋白質(zhì)互作分析,證實(shí)AFAP1與KRAS結(jié)合調(diào)控細(xì)胞應(yīng)力纖維形成,影響結(jié)直腸癌細(xì)胞的遷移能力。

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以上文獻(xiàn)均涉及AFAP1抗體在腫瘤機(jī)制或診斷中的應(yīng)用,涵蓋分子機(jī)制、預(yù)后評(píng)估及信號(hào)通路研究。如需具體DOI或年份,可進(jìn)一步補(bǔ)充關(guān)鍵詞檢索。

       

背景信息

The AFAP1 (Actin Filament-Associated Protein 1) antibody is a research tool targeting AFAP1. a scaffolding protein involved in cytoskeletal organization and cellular signaling. AFAP1 interacts with actin filaments and signaling molecules like Src kinases, playing roles in cell adhesion, migration, and invasion. Its dysregulation is linked to cancer progression, particularly in tumors with enhanced metastatic potential, such as breast, lung, and pancreatic cancers.

AFAP1 antibodies are widely used in studies to detect AFAP1 expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate AFAP1's molecular mechanisms in tumorigenesis, including its role in modulating invadopodia formation, extracellular matrix degradation, and epithelial-mesenchymal transition (EMT).

Recent research highlights AFAP1's involvement in crosstalk between cytoskeletal dynamics and oncogenic signaling pathways, such as FAK/Src and PI3K/AKT. Commercially available AFAP1 antibodies are typically validated for specificity across human and murine samples, aiding translational studies. However, variability in antibody performance (e.g., cross-reactivity) necessitates careful validation for experimental conditions. Overall, AFAP1 antibodies are critical for advancing understanding of cancer biology and potential therapeutic targeting of metastasis-related pathways.

       
關(guān)鍵字: AFAP1抗體;AFAP1;AFAP1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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AFAP1抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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