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SPARC抗體,Rabbit Polyclonal SPARC Antibody
  • SPARC抗體,Rabbit Polyclonal SPARC Antibody
  • SPARC抗體,Rabbit Polyclonal SPARC Antibody
  • SPARC抗體,Rabbit Polyclonal SPARC Antibody

SPARC抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SPARC抗體英文名稱:Rabbit Polyclonal SPARC Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3643 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: SPARC
2025-05-13 SPARC抗體 Rabbit Polyclonal SPARC Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3643 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

WB Predicted band size35 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human SPARC
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A375 cells, Primary antibody: P07619(SPARC Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07619(SPARC Antibody) at dilution 1/35. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于SPARC抗體的3篇代表性文獻的簡要概述:

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1. **文獻名稱**:*"SPARC expression by stromal cells regulates tumor growth and angiogenesis in human melanoma"*

**作者**:Rempel SA, Golembieski WA, Fisher JL, Maile M, Nakeff A

**摘要**:該研究利用SPARC抗體檢測黑色素瘤基質(zhì)中的表達,發(fā)現(xiàn)SPARC通過抑制血管生成和調(diào)節(jié)細胞外基質(zhì)重塑,顯著減緩腫瘤生長,提示其抗腫瘤作用。

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2. **文獻名稱**:*"Targeting SPARC expression in glioma microenvironment"*

**作者**:Golembieski WA, Thomas SL, Schultz CR, Yunker CK, McClung HM, Lemke N

**摘要**:通過SPARC抗體分析膠質(zhì)瘤微環(huán)境,發(fā)現(xiàn)SPARC高表達與腫瘤侵襲性增強及患者預(yù)后不良相關(guān),為靶向SPARC的治療策略提供依據(jù)。

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3. **文獻名稱**:*"SPARC regulates collagen interaction and deposition in the extracellular matrix"*

**作者**:Bradshaw AD, Sage EH

**摘要**:研究應(yīng)用SPARC抗體探究細胞外基質(zhì)中膠原的動態(tài)變化,證實SPARC通過調(diào)控膠原纖維組裝影響組織纖維化進程,尤其在心臟和腎臟疾病中作用顯著。

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**備注**:上述文獻涵蓋腫瘤微環(huán)境、纖維化機制等方向,展示了SPARC抗體在基礎(chǔ)研究與臨床中的應(yīng)用。如需具體發(fā)表年份或期刊信息,可進一步補充。

       

背景信息

SPARC (Secreted Protein Acidic and Rich in Cysteine), also known as osteonectin or BM-40. is a multifunctional glycoprotein involved in regulating cell-matrix interactions. It is a key component of the extracellular matrix (ECM) and modulates cellular processes such as proliferation, migration, differentiation, and apoptosis by interacting with structural proteins (e.g., collagen) and growth factors (e.g., TGF-β, VEGF). SPARC is highly expressed in tissues undergoing remodeling, including bone, cartilage, and injured or diseased organs, and is implicated in fibrosis, inflammation, angiogenesis, and tumor progression.

SPARC antibodies are tools used to detect and study the protein's expression, localization, and function in both physiological and pathological contexts. In cancer research, SPARC antibodies help assess its dual role as a tumor suppressor (inhibiting cell cycle progression) or tumor promoter (enhancing metastasis via ECM remodeling), depending on cancer type and microenvironment. They are also employed in fibrosis studies (e.g., liver, kidney) and metabolic disorders (e.g., diabetes), where SPARC overexpression correlates with tissue stiffness and dysfunction.

Therapeutically, SPARC antibodies are explored for targeted drug delivery due to SPARC's affinity for albumin and nanoparticles, potentially improving chemotherapy efficacy. However, challenges like off-target effects and variable expression levels across tissues limit clinical applications. Research continues to clarify SPARC's context-dependent mechanisms and optimize antibody-based strategies for diagnostics and treatments.

       
關(guān)鍵字: SPARC抗體;SPARC;SPARC Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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