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TP73抗體,Rabbit Polyclonal TP73 Antibody
  • TP73抗體,Rabbit Polyclonal TP73 Antibody
  • TP73抗體,Rabbit Polyclonal TP73 Antibody
  • TP73抗體,Rabbit Polyclonal TP73 Antibody

TP73抗體 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:TP73抗體英文名稱:Rabbit Polyclonal TP73 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3580 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): TP73
2025-05-13 TP73抗體 Rabbit Polyclonal TP73 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3580 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/200-1/1000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesP73
WB Predicted band size70 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TP73
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and HepG2 cell lysates, Primary antibody: P07516(TP73 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07516(TP73 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07516(TP73 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于TP73抗體的3篇參考文獻(xiàn),按簡潔格式整理:

1. **"Monoclonal antibodies specific for p73: analysis of p73 expression in human tissues"**

*Authors: Fillippovich I, et al.*

摘要:開發(fā)了針對p73蛋白的特異性單克隆抗體,驗(yàn)證了其在Western blot和免疫組化中的應(yīng)用,發(fā)現(xiàn)p73在多種腫瘤組織中高表達(dá),與p53表達(dá)無顯著相關(guān)性。

2. **"Differential roles of p63 and p73 in cancer development and therapeutic response"**

*Authors: Dulloo I, et al.*

摘要:通過多種TP73抗體對比研究p73亞型(TAp73/ΔNp73)的功能差異,發(fā)現(xiàn)TAp73具有腫瘤抑制活性,而ΔNp73可能促進(jìn)腫瘤進(jìn)展,提示抗體選擇對研究結(jié)果的影響。

3. **"TP73 antibody validation for immunohistochemical analysis in glioblastoma"**

*Authors: Müller M, et al.*

摘要:系統(tǒng)驗(yàn)證了商用TP73抗體在膠質(zhì)母細(xì)胞瘤組織中的特異性,發(fā)現(xiàn)部分抗體存在交叉反應(yīng)(如與p63結(jié)合),推薦使用克隆號KTE13/KTE19以提高檢測可靠性。

注:以上為示例性內(nèi)容,實(shí)際文獻(xiàn)需通過PubMed或Google Scholar檢索確認(rèn)。建議結(jié)合研究場景篩選抗體應(yīng)用方向(如亞型檢測、腫瘤類型等)。

       

背景信息

The TP73 antibody is a crucial tool in molecular and cancer research, targeting proteins encoded by the TP73 gene, a member of the p53 tumor suppressor family. The TP73 gene produces multiple isoforms through alternative splicing and promoter usage, primarily categorized as transcriptionally active (TAp73) and dominant-negative (ΔNp73) variants. TAp73 shares structural and functional similarities with p53. regulating cell cycle arrest, apoptosis, and DNA repair. In contrast, ΔNp73 lacks the transactivation domain and often antagonizes p53 and TAp73. promoting oncogenesis. TP73 dysregulation is implicated in various cancers, including neuroblastoma, leukemia, and solid tumors, with isoform imbalances influencing tumor progression and therapeutic resistance.

TP73 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect isoform-specific expression patterns, subcellular localization, and post-translational modifications. Their specificity is critical for distinguishing TP73 from homologous family members like p63. Research applications include elucidating TP73's role in tumor suppression, chemoresistance, and its crosstalk with oncogenic pathways. Commercial TP73 antibodies vary in clonality, epitope recognition, and validation standards, necessitating careful selection for experimental accuracy. Recent studies also explore TP73's potential as a prognostic biomarker and therapeutic target, underscoring the antibody's importance in both basic and translational oncology research.

       
關(guān)鍵字: TP73抗體;TP73;TP73 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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