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NFATC3抗體,Rabbit Polyclonal NFATC3 Antibody
  • NFATC3抗體,Rabbit Polyclonal NFATC3 Antibody
  • NFATC3抗體,Rabbit Polyclonal NFATC3 Antibody
  • NFATC3抗體,Rabbit Polyclonal NFATC3 Antibody

NFATC3抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:NFATC3抗體英文名稱:Rabbit Polyclonal NFATC3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3563 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: NFATC3
2025-05-13 NFATC3抗體 Rabbit Polyclonal NFATC3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3563 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesNFAT4; NFATX
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human NFATC3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07480(NFATC3 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07480(NFATC3 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于NFATC3抗體的示例參考文獻(內(nèi)容為模擬虛構(gòu),僅供參考,建議通過學(xué)術(shù)數(shù)據(jù)庫核實真實文獻):

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1. **"NFATC3 regulates tumor angiogenesis via transcriptional control of VEGF in breast cancer"**

*Authors: Zhang L, et al.*

**摘要**:本研究通過免疫組化及Western blot分析,利用NFATC3特異性抗體發(fā)現(xiàn)其在乳腺癌組織中高表達,并證實NFATC3通過結(jié)合VEGF啟動子促進血管生成,提示其作為治療靶點的潛力。

2. **"NFATC3 nuclear translocation in T-cell activation: A flow cytometry-based approach"**

*Authors: Rivera M, et al.*

**摘要**:通過流式細胞術(shù)和免疫熒光技術(shù)結(jié)合NFATC3抗體,揭示了T細胞活化過程中NFATC3的核轉(zhuǎn)位動力學(xué)及其與IL-2分泌的調(diào)控關(guān)系,為免疫調(diào)節(jié)機制提供新見解。

3. **"Targeting NFATC3 in cardiac hypertrophy: Insights from knockout mouse models"**

*Authors: Chen H, et al.*

**摘要**:利用NFATC3抗體檢測基因敲除小鼠心臟組織,發(fā)現(xiàn)NFATC3缺失可抑制病理性心肌肥厚相關(guān)基因(如ANP)的表達,表明其在心臟疾病中的關(guān)鍵作用。

4. **"NFATC3 interacts with HDAC4 to modulate osteoclast differentiation"**

*Authors: Kim S, et al.*

**摘要**:通過Co-IP和ChIP實驗結(jié)合NFATC3抗體,證明NFATC3與組蛋白去乙?;窰DAC4形成復(fù)合物,共同調(diào)控破骨細胞分化關(guān)鍵基因TRAP的表達。

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建議通過PubMed或Google Scholar搜索關(guān)鍵詞“NFATC3 antibody”、“NFATC3 function”或結(jié)合具體研究領(lǐng)域(如癌癥、免疫、心血管疾病)獲取真實文獻。

       

背景信息

The nuclear factor of activated T cells 3 (NFATC3), a member of the NFAT transcription factor family, plays a critical role in immune response regulation, cell differentiation, and development. NFAT proteins are calcium-sensitive regulators that translocate to the nucleus upon dephosphorylation by calcineurin, enabling transcriptional activation of target genes. NFATC3. encoded by the *NFATC3* gene, is expressed in immune cells (e.g., T cells), muscle tissues, and the nervous system. It regulates cytokine production, vascular development, and cardiac hypertrophy, and has been implicated in pathological conditions, including cancer, autoimmune diseases, and cardiovascular disorders. Unlike other NFAT isoforms, NFATC3 may exhibit distinct roles in cellular stress responses and oncogenic signaling pathways.

NFATC3 antibodies are essential tools for detecting and quantifying NFATC3 protein expression, localization, and post-translational modifications. These antibodies are widely used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry to study NFATC3's dynamic shuttling between the cytoplasm and nucleus, its interaction partners, and its regulatory mechanisms. Specific NFATC3 antibodies help differentiate it from other NFAT family members (e.g., NFATC1. NFATC2) due to isoform-specific epitopes. Validation often includes knockout cell lines or siRNA knockdown to confirm specificity. Researchers utilize these antibodies to explore NFATC3's dual roles in immune regulation and disease pathogenesis, particularly its context-dependent pro- or anti-tumor effects and contributions to inflammatory signaling. Understanding NFATC3 dynamics aids in developing therapeutic strategies targeting calcineurin-NFAT pathways.

       
關(guān)鍵字: NFATC3抗體;NFATC3;NFATC3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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