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ING2抗體,Rabbit Polyclonal ING2 Antibody
  • ING2抗體,Rabbit Polyclonal ING2 Antibody
  • ING2抗體,Rabbit Polyclonal ING2 Antibody
  • ING2抗體,Rabbit Polyclonal ING2 Antibody

ING2抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ING2抗體英文名稱:Rabbit Polyclonal ING2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3513 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): ING2
2025-05-13 ING2抗體 Rabbit Polyclonal ING2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3513 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesING1L; p33ING2
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human ING2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Lovo cells, human liver cancer tissue, mouse kidney tissue, Primary antibody: P07382(ING2 Antibody) at dilution 1/425, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07382(ING2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07382(ING2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇與ING2抗體相關(guān)的參考文獻(xiàn),按研究主題和內(nèi)容簡(jiǎn)要概括:

1. **"ING2 regulates chromatin structure and gene expression by modulating histone H3K4 methylation"**

*作者:Garkavtsev et al. (2004)*

**摘要**:研究揭示了ING2通過(guò)結(jié)合組蛋白H3K4me3并招募組蛋白去乙?;?HDAC)復(fù)合體,調(diào)控染色質(zhì)結(jié)構(gòu)和基因表達(dá)的功能。實(shí)驗(yàn)使用ING2抗體進(jìn)行免疫沉淀和染色質(zhì)免疫共沉淀(ChIP),證實(shí)其在抑制腫瘤生長(zhǎng)中的關(guān)鍵作用。

2. **"The tumor suppressor ING2 mediates epigenetic regulation of cellular senescence"**

*作者:Thalappilly et al. (2010)*

**摘要**:通過(guò)免疫組織化學(xué)(IHC)和Western blot分析,研究證明ING2抗體檢測(cè)到的蛋白表達(dá)水平與細(xì)胞衰老和DNA損傷修復(fù)相關(guān)。ING2缺失導(dǎo)致表觀遺傳修飾異常,促進(jìn)腫瘤發(fā)生。

3. **"ING2 interacts with p300/CBP to enhance p53 acetylation and transcriptional activity"**

*作者:Kuo et al. (2008)*

**摘要**:文章利用ING2抗體進(jìn)行共聚焦顯微成像和免疫共沉淀實(shí)驗(yàn),發(fā)現(xiàn)ING2通過(guò)結(jié)合p300/CBP復(fù)合體增強(qiáng)p53的乙?;?,進(jìn)而激活促凋亡基因,抑制腫瘤進(jìn)展。

4. **"Loss of ING2 expression predicts poor prognosis in hepatocellular carcinoma"**

*作者:Unoki et al. (2011)*

**摘要**:臨床樣本分析中,ING2抗體的免疫組化結(jié)果顯示,ING2低表達(dá)與肝癌患者生存率下降顯著相關(guān),提示其作為預(yù)后生物標(biāo)志物的潛力。

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**備注**:以上文獻(xiàn)標(biāo)題和作者為模擬示例,實(shí)際引用需以真實(shí)出版物為準(zhǔn)。建議通過(guò)PubMed或Google Scholar以關(guān)鍵詞“ING2 antibody”、“ING2 function”或“ING2 cancer”檢索最新研究。

       

背景信息

The ING2 (Inhibitor of Growth 2) antibody is a research tool used to detect and study the ING2 protein, a member of the ING family of tumor suppressors. ING2 is a nuclear protein involved in chromatin remodeling, transcriptional regulation, and cellular stress responses. It interacts with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes, modulating histone acetylation status to influence gene expression. ING2 plays roles in cell cycle arrest, apoptosis, DNA repair, and senescence, often acting as a tumor suppressor by regulating p53-dependent pathways. Dysregulation of ING2 has been linked to cancers, neurodegenerative diseases, and aging.

The ING2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions in cell lines or tissues. Researchers utilize it to explore ING2's involvement in epigenetic regulation, cancer progression, and therapeutic responses. Specificity and validation (e.g., knockout controls) are critical due to potential cross-reactivity with other ING family members. Commercial antibodies often target epitopes within the N-terminal region or plant homeodomain (PHD) zinc finger, which are essential for ING2's chromatin-binding activity. Studies employing this antibody have revealed ING2's downregulation in certain malignancies and its role in oxidative stress responses, making it a focal point in both basic and translational cancer research.

       
關(guān)鍵字: ING2抗體;ING2;ING2 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤(pán)

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ING2抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
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VIP3年
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2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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