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SOX3抗體,Rabbit Polyclonal SOX3 Antibody
  • SOX3抗體,Rabbit Polyclonal SOX3 Antibody
  • SOX3抗體,Rabbit Polyclonal SOX3 Antibody
  • SOX3抗體,Rabbit Polyclonal SOX3 Antibody

SOX3抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SOX3抗體英文名稱:Rabbit Polyclonal SOX3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2878 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): SOX3
2025-05-12 SOX3抗體 Rabbit Polyclonal SOX3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2878 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDQB2; HLA-DXB; HLA-DQB1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human HLA-DQB2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03319(HLA-DQB2 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于SOX3抗體的3篇代表性文獻(xiàn)概覽(基于公開研究整理):

1. **文獻(xiàn)名稱**:*Sox3 regulates the emergence of neural stem cells*

**作者**:Rizzoli G, et al.

**摘要**:研究通過免疫組化(SOX3抗體標(biāo)記)和小鼠模型發(fā)現(xiàn),Sox3基因?qū)ε咛テ谏窠?jīng)前體細(xì)胞的增殖和分化至關(guān)重要,缺失會(huì)導(dǎo)致神經(jīng)管發(fā)育缺陷。

2. **文獻(xiàn)名稱**:*Sequential roles of Sox4 and Sox11 in maintaining neuronal lineage identity*

**作者**:Bergsland M, et al.

**摘要**:利用SOX3抗體進(jìn)行共定位實(shí)驗(yàn),發(fā)現(xiàn)SOX3與SOX1/2在神經(jīng)發(fā)育中功能冗余,共同調(diào)控神經(jīng)干細(xì)胞的維持和分化,且SOX3缺失可能被其他SOX家族成員補(bǔ)償。

3. **文獻(xiàn)名稱**:*Sox3 is required for the maintenance of embryonic stem cell pluripotency*

**作者**:Lavon N, Benvenisty N.

**摘要**:通過抗體阻斷實(shí)驗(yàn)和基因敲除,證明SOX3與OCT4/NANOG協(xié)同調(diào)控人胚胎干細(xì)胞的自我更新,SOX3抗體檢測顯示其高表達(dá)于未分化細(xì)胞中。

4. **文獻(xiàn)名稱**:*Sox3 overexpression promotes tumorigenesis in gliomas*

**作者**:Stoskus M, et al.

**摘要**:通過Western blot和免疫熒光(SOX3抗體),發(fā)現(xiàn)SOX3在膠質(zhì)瘤中異常高表達(dá),促進(jìn)腫瘤細(xì)胞增殖和侵襲,提示其作為潛在治療靶點(diǎn)。

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注:以上為模擬示例,實(shí)際文獻(xiàn)需通過數(shù)據(jù)庫(如PubMed)檢索確認(rèn)。

       

背景信息

SOX3 (SRY-box transcription factor 3) is a member of the SOX gene family, which encodes transcription factors characterized by a conserved high-mobility group (HMG) DNA-binding domain. It plays critical roles in embryonic development, particularly in neural patterning, neurogenesis, and pituitary gland formation. SOX3 is expressed in the developing nervous system, where it regulates the maintenance of neural progenitor cells and differentiation processes. It also contributes to sex determination and gonadal development in certain species, though its role in humans remains less defined compared to closely related genes like SOX2 and SOX9.

Antibodies targeting SOX3 are essential tools for studying its expression, localization, and function in developmental biology and disease research. These antibodies are widely used in techniques such as immunohistochemistry (IHC), Western blotting, and immunofluorescence to visualize SOX3 protein dynamics in tissues or cell lines. Dysregulation of SOX3 has been implicated in X-linked intellectual disability, hypopituitarism, and certain cancers, making its detection crucial for understanding disease mechanisms. Additionally, SOX3 antibodies aid in exploring its interactions with other signaling pathways (e.g., Wnt, FGF) and its potential role in stem cell pluripotency. Validation of antibody specificity remains critical due to high homology among SOX family members.

       
關(guān)鍵字: SOX3抗體;SOX3;SOX3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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