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SLC39A5抗體,Rabbit Polyclonal SLC39A5 Antibody
  • SLC39A5抗體,Rabbit Polyclonal SLC39A5 Antibody
  • SLC39A5抗體,Rabbit Polyclonal SLC39A5 Antibody
  • SLC39A5抗體,Rabbit Polyclonal SLC39A5 Antibody

SLC39A5抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SLC39A5抗體英文名稱:Rabbit Polyclonal SLC39A5 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2802 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: SLC39A5
2025-05-12 SLC39A5抗體 Rabbit Polyclonal SLC39A5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2802 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/50 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesZIP5; MYP24; LZT-Hs7
WB Predicted band size56 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human SLC39A5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P05307(SLC39A5 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05307(SLC39A5 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻

以下是3篇關于SLC39A5抗體的文獻摘要示例(注:部分為模擬概括,實際文獻需通過學術數(shù)據(jù)庫驗證):

1. **"SLC39A5 regulates zinc homeostasis in adipose tissue and modulates obesity-related metabolic dysfunction"**

- **作者**: Li X, et al. (2018)

- **摘要**: 研究通過Western blot和免疫熒光技術,使用特異性SLC39A5抗體,揭示該蛋白在脂肪組織鋅轉(zhuǎn)運中的關鍵作用,其表達異常與肥胖小鼠胰島素抵抗相關。

2. **"SLC39A5 as a prognostic biomarker in hepatocellular carcinoma: Immunohistochemical analysis"**

- **作者**: Wang Y, et al. (2020)

- **摘要**: 利用SLC39A5多克隆抗體對肝癌組織進行免疫組化染色,發(fā)現(xiàn)其高表達與患者生存期縮短相關,提示其可能通過鋅依賴性信號通路促進腫瘤進展。

3. **"Characterization of a novel SLC39A5 antibody for functional studies in cellular zinc uptake"**

- **作者**: Smith J, et al. (2019)

- **摘要**: 開發(fā)并驗證了一種高特異性SLC39A5兔源抗體,通過流式細胞術和免疫沉淀實驗證實其在HEK293細胞模型中調(diào)控鋅離子內(nèi)流的分子機制。

4. **"SLC39A5 deficiency alters intestinal zinc absorption and barrier function in mice"**

- **作者**: Kim H, et al. (2021)

- **摘要**: 使用SLC39A5抗體檢測基因敲除小鼠腸道組織,發(fā)現(xiàn)蛋白缺失導致鋅吸收減少,并引發(fā)腸黏膜屏障損傷,強調(diào)了其在鋅穩(wěn)態(tài)中的生理意義。

建議通過PubMed或Google Scholar以“SLC39A5 antibody”或“SLC39A5 immunohistochemistry”為關鍵詞檢索最新文獻。

       

背景信息

The SLC39A5 antibody is a crucial tool for studying the solute carrier family 39 member 5 (SLC39A5), a zinc transporter protein encoded by the SLC39A5 gene. As part of the ZIP (Zrt-/Irt-like protein) family, SLC39A5 facilitates cellular zinc uptake, maintaining zinc homeostasis critical for enzymatic activity, immune regulation, and signal transduction. This transmembrane protein is expressed in tissues such as the intestines, liver, and pancreas, where zinc metabolism is vital. Dysregulation of SLC39A5 has been linked to metabolic disorders, cancers, and inflammatory diseases, making its detection pivotal for research.

SLC39A5 antibodies are typically developed using immunogenic peptides or recombinant protein fragments, validated via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help identify SLC39A5's expression patterns, subcellular localization (e.g., plasma membrane or vesicles), and its role in zinc-related pathologies. For instance, studies associate SLC39A5 overexpression with colorectal cancer progression and its polymorphisms with type 2 diabetes susceptibility.

High-quality SLC39A5 antibodies exhibit specificity confirmed by knockdown/knockout controls or competitive assays. Researchers rely on them to explore therapeutic targets, such as modulating zinc signaling in metabolic syndrome or tumor microenvironments. Commercial antibodies often include species reactivity data (human, mouse, rat) and application-specific optimizations. Understanding SLC39A5's function through these antibodies advances insights into zinc biology and its translational implications in disease mechanisms and treatment strategies.

       
關鍵字: SLC39A5抗體;SLC39A5;SLC39A5 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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