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PRAF2抗體,Rabbit Polyclonal PRAF2 Antibody
  • PRAF2抗體,Rabbit Polyclonal PRAF2 Antibody
  • PRAF2抗體,Rabbit Polyclonal PRAF2 Antibody
  • PRAF2抗體,Rabbit Polyclonal PRAF2 Antibody

PRAF2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PRAF2抗體英文名稱:Rabbit Polyclonal PRAF2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2779 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: PRAF2
2025-05-12 PRAF2抗體 Rabbit Polyclonal PRAF2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2779 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesJM4
WB Predicted band size19 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human PRAF2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal brain tissue, A549 cells, hela cells, 293T cells, Primary antibody: P05240(PRAF2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05240(PRAF2 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于PRAF2抗體的3篇參考文獻示例(注:以下內(nèi)容為模擬示例,非真實文獻):

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1. **文獻名稱**: *PRAF2 modulates apoptosis signaling through interaction with Bcl-2 family proteins*

**作者**: Li X, Zhang Y, et al.

**摘要**: 本研究利用PRAF2特異性抗體,通過免疫共沉淀和Western blot技術(shù),揭示了PRAF2與Bcl-2家族蛋白的相互作用機制,證明其在調(diào)控線粒體途徑細胞凋亡中的作用,為癌癥治療靶點研究提供依據(jù)。

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2. **文獻名稱**: *Overexpression of PRAF2 in hepatocellular carcinoma and its clinical significance*

**作者**: Wang H, Chen J, et al.

**摘要**: 通過免疫組化(使用PRAF2多克隆抗體)分析肝癌組織樣本,發(fā)現(xiàn)PRAF2在肝癌中高表達且與患者預(yù)后不良相關(guān),提示其可能作為肝癌診斷的潛在生物標志物。

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3. **文獻名稱**: *Development and validation of a novel monoclonal antibody against human PRAF2 for flow cytometry applications*

**作者**: Smith KA, Brown R, et al.

**摘要**: 本文報道了一種針對人源PRAF2的新型單克隆抗體的開發(fā)與驗證,該抗體在流式細胞術(shù)中表現(xiàn)出高特異性和靈敏度,成功應(yīng)用于白血病細胞系的表面蛋白定量分析。

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如需真實文獻,建議通過PubMed或Google Scholar以關(guān)鍵詞“PRAF2 antibody”、“PRAF2 function”進行檢索,并篩選近五年內(nèi)與您研究領(lǐng)域相關(guān)的論文。

       

背景信息

The PRAF2 (Prenylated Rab Acceptor 1 Family Member 2) protein, also known as RAPH1. is a member of the PRAF family involved in intracellular vesicular trafficking and membrane dynamics. It interacts with prenylated Rab GTPases, facilitating their proper subcellular localization and function in secretory pathways. PRAF2 is predominantly localized to the Golgi apparatus and endoplasmic reticulum, playing roles in maintaining organelle integrity and regulating protein transport. Studies suggest its involvement in apoptosis, where it may act as a pro-apoptotic factor by interacting with Bcl-2 family proteins or modulating mitochondrial pathways.

Aberrant PRAF2 expression has been linked to human diseases, particularly cancers. Overexpression is observed in certain tumors, correlating with poor prognosis, tumor progression, and metastasis, potentially through pathways affecting cell proliferation, migration, or chemoresistance. Conversely, reduced expression has been implicated in neurodevelopmental disorders, highlighting its tissue-specific roles.

PRAF2 antibodies are essential tools for detecting protein expression, localization, and interaction partners in research. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of PRAF2’s biological functions and pathological mechanisms. Commercial antibodies are typically generated using recombinant protein fragments or synthetic peptides, with validation across experimental models. Ongoing research focuses on clarifying PRAF2’s dual roles in cancer and neurological processes, positioning it as a potential diagnostic marker or therapeutic target.

       
關(guān)鍵字: PRAF2抗體;PRAF2;PRAF2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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