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RAC2抗體,Rabbit Polyclonal RAC2 Antibody
  • RAC2抗體,Rabbit Polyclonal RAC2 Antibody
  • RAC2抗體,Rabbit Polyclonal RAC2 Antibody
  • RAC2抗體,Rabbit Polyclonal RAC2 Antibody

RAC2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:RAC2抗體英文名稱:Rabbit Polyclonal RAC2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2766 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: RAC2
2025-05-12 RAC2抗體 Rabbit Polyclonal RAC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2766 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/500-1/1000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGx; EN-7; HSPC022; p21-Rac2
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human RAC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: K562 cell, 293T cell, Jurkat cell lysates, Primary antibody: P05204(RAC2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05204(RAC2 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻

以下是關于RAC2抗體的3篇參考文獻及其摘要概括:

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1. **文獻名稱**:*Rac2 regulates neutrophil chemotaxis, superoxide production, and cell polarization in response to fMLP*

**作者**:Williams DA, Tao W, Yang F, et al.

**摘要**:該研究利用RAC2特異性抗體,驗證了RAC2蛋白在嗜中性粒細胞中的表達及功能。實驗表明,RAC2通過調(diào)控細胞骨架重組和NADPH氧化酶活性,影響細胞的趨化性和氧化爆發(fā)反應,為免疫缺陷疾病(如RAC2突變相關疾病)的機制提供了依據(jù)。

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2. **文獻名稱**:*Rac2 controls the dynamics of T cell receptor signaling by regulating F-actin and the cellular localization of Lck and ZAP-70*

**作者**:Gu Y, Chae HD, Siefring JE, et al.

**摘要**:研究利用RAC2抗體進行免疫印跡和免疫熒光,揭示了RAC2在T細胞受體信號轉(zhuǎn)導中的關鍵作用。結果顯示,RAC2通過調(diào)控F-肌動蛋白重塑,影響Lck和ZAP-70的亞細胞定位,從而調(diào)節(jié)T細胞活化及免疫應答。

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3. **文獻名稱**:*Structural and functional characterization of Rac2 mutations in neutrophil immunodeficiency disorders*

**作者**:Roberts AW, Kim C.

**摘要**:該文獻通過RAC2抗體檢測患者來源的突變型RAC2蛋白,結合結構分析,闡明了不同突變(如D57N)對RAC2 GTP酶活性及下游信號通路的影響,為先天性免疫缺陷的診斷和治療提供了分子機制支持。

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**備注**:以上文獻為示例性質(zhì),實際引用時建議通過PubMed或Google Scholar核對最新研究。若需實驗抗體品牌或具體應用場景(如WB、IF等),可補充說明進一步篩選。

       

背景信息

**Background of RAC2 Antibody**

RAC2 (Ras-related C3 botulinum toxin substrate 2) is a small GTPase belonging to the Rho family, primarily expressed in hematopoietic cells, including neutrophils, macrophages, and lymphocytes. It plays a critical role in regulating cellular processes such as cytoskeletal reorganization, cell migration, phagocytosis, and reactive oxygen species (ROS) production. RAC2 cycles between an inactive GDP-bound state and an active GTP-bound state, interacting with downstream effectors to mediate signaling pathways involved in immune response and inflammation.

RAC2 antibodies are immunological tools designed to detect and quantify RAC2 protein expression in research and diagnostic applications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), flow cytometry, and immunofluorescence (IF) to study RAC2's role in immune cell function and disease mechanisms. Dysregulation of RAC2 is linked to immunodeficiency disorders (e.g., severe combined immunodeficiency, SCID) and inflammatory/autoimmune conditions. Additionally, RAC2 mutations are associated with neutrophil dysfunction and cancer progression, highlighting its therapeutic and diagnostic relevance.

Validating RAC2 antibodies requires specificity testing via knockout controls or siRNA knockdown to ensure accurate detection. Their development has advanced research into immune cell signaling, offering insights into potential drug targets for modulating immune responses or treating RAC2-related pathologies.

       
關鍵字: RAC2抗體;RAC2;RAC2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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