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OTOR抗體,Rabbit Polyclonal OTOR Antibody
  • OTOR抗體,Rabbit Polyclonal OTOR Antibody
  • OTOR抗體,Rabbit Polyclonal OTOR Antibody
  • OTOR抗體,Rabbit Polyclonal OTOR Antibody

OTOR抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:OTOR抗體英文名稱:Rabbit Polyclonal OTOR Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2741 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): OTOR
2025-05-12 OTOR抗體 Rabbit Polyclonal OTOR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2741 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesFDP; MIAL1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human OTOR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P05123(OTOR Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P05123(OTOR Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于OTOR抗體的3篇代表性文獻(xiàn)的簡要信息:

1. **文獻(xiàn)名稱**:*Otoraplin (OTOR) expression in the developing mouse cochlea: implications for auditory function*

**作者**:Smith J, et al.

**摘要**:本研究利用OTOR特異性抗體,通過免疫組化和Western blot分析,揭示了OTOR蛋白在小鼠耳蝸發(fā)育中的時(shí)空表達(dá)模式,提示其在毛細(xì)胞分化和聽覺信號傳導(dǎo)中的潛在作用。

2. **文獻(xiàn)名稱**:*Characterization of a novel polyclonal antibody against human OTOR and its application in hearing loss studies*

**作者**:Lee H, et al.

**摘要**:文章報(bào)道了一種新型兔源多克隆OTOR抗體的制備與驗(yàn)證,該抗體成功用于檢測內(nèi)耳組織及細(xì)胞系中的OTOR蛋白,為遺傳性耳聾患者的蛋白表達(dá)缺失分析提供了工具。

3. **文獻(xiàn)名稱**:*OTOR deficiency disrupts vestibular function in zebrafish: Insights from antibody-based protein localization*

**作者**:Garcia R, et al.

**摘要**:通過OTOR抗體進(jìn)行免疫熒光染色,研究發(fā)現(xiàn)OTOR蛋白在斑馬魚前庭器官中的特異性分布,其基因敲除導(dǎo)致平衡功能障礙,支持OTOR在內(nèi)耳穩(wěn)態(tài)中的保守作用。

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**說明**:

- OTOR(Otoraplin)相關(guān)研究較少,上述文獻(xiàn)為假設(shè)性示例,實(shí)際文獻(xiàn)可能需要通過PubMed、Google Scholar等平臺(tái)以“OTOR antibody”“otoraplin immunohistochemistry”等關(guān)鍵詞檢索。

- 若需具體文獻(xiàn),建議補(bǔ)充研究背景(如疾病關(guān)聯(lián)或?qū)嶒?yàn)技術(shù)),以便精準(zhǔn)定位。

       

背景信息

OTOR antibodies are tools used to study the OTOR protein (also known as FAM11B or FcRL4), a member of the Fc receptor-like (FCRL) family. OTOR is primarily expressed in B-cells and certain epithelial tissues, where it modulates immune responses by influencing B-cell receptor (BCR) signaling and interactions with other immune receptors. Structurally, it contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs), suggesting a regulatory role in dampening B-cell activation. Dysregulation of OTOR has been linked to autoimmune disorders, lymphomas, and chronic inflammatory conditions, making it a focus in immunopathology research.

OTOR antibodies are generated as monoclonal or polyclonal reagents to detect the protein’s expression, localization, and post-translational modifications. They are critical for techniques like Western blotting, immunohistochemistry, and flow cytometry, enabling researchers to explore OTOR’s tissue-specific functions and pathological mechanisms. Recent studies highlight OTOR’s potential as a therapeutic target, particularly in diseases characterized by aberrant B-cell activity, such as rheumatoid arthritis or B-cell malignancies. However, its exact physiological roles remain under investigation, partly due to interspecies variability and complex signaling crosstalk. Validated OTOR antibodies thus serve as essential reagents to dissect its contributions to immune regulation and disease progression, bridging gaps in understanding its dual roles in homeostasis and pathology.

       
關(guān)鍵字: OTOR抗體;OTOR;OTOR Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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