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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, hepG2 cells, Primary antibody: P04845(AIMP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04845(AIMP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P04845(AIMP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The AIMP1 (aminoacyl tRNA synthase complex-interacting multifunctional protein 1) antibody is a tool used to detect and study AIMP1. a multifunctional protein initially identified as a component of the multi-synthetase complex (MSC) involved in protein synthesis. Beyond its role in tRNA aminoacylation, AIMP1 exhibits extracellular cytokine-like activity under stress conditions, regulating inflammation, angiogenesis, and apoptosis. It is also known as EMAP II (endothelial monocyte-activating polypeptide II) or SCYE1. and its dysregulation is linked to cancer, neurodegenerative disorders, and autoimmune diseases.

AIMP1 antibodies, both monoclonal and polyclonal, are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate AIMP1’s dual intracellular and extracellular functions. These antibodies help elucidate its role in pathological processes, such as promoting apoptosis in tumor cells or modulating immune responses. Researchers often produce AIMP1 antibodies by immunizing hosts with recombinant AIMP1 protein or synthetic peptides corresponding to specific epitopes. Validation typically involves knockout cell lines or siRNA-mediated knockdown to confirm target specificity. Due to AIMP1’s structural homology with other MSC components, antibody specificity is critical to avoid cross-reactivity. Its involvement in diverse pathways makes AIMP1 a compelling target for therapeutic and diagnostic research, particularly in oncology and neuroinflammation studies.