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ADRA1B抗體,Rabbit Polyclonal ADRA1B Antibody
  • ADRA1B抗體,Rabbit Polyclonal ADRA1B Antibody
  • ADRA1B抗體,Rabbit Polyclonal ADRA1B Antibody
  • ADRA1B抗體,Rabbit Polyclonal ADRA1B Antibody

ADRA1B抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ADRA1B抗體英文名稱:Rabbit Polyclonal ADRA1B Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2594 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): ADRA1B
2025-05-12 ADRA1B抗體 Rabbit Polyclonal ADRA1B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2594 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesADRA1, ALPHA1BAR
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ADRA1B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lung cancer tissue, Primary antibody: P03771(ADRA1B Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P03771(ADRA1B Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P03771(ADRA1B Antibody) at dilution 1/20. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于ADRA1B抗體的3篇參考文獻(xiàn)的簡(jiǎn)要信息(注:文獻(xiàn)信息為示例性概括,具體內(nèi)容需通過(guò)學(xué)術(shù)數(shù)據(jù)庫(kù)核實(shí)):

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1. **文獻(xiàn)名稱**: "Characterization of α1B-adrenergic receptor phosphorylation and desensitization"

**作者**: Garcia-Sainz, J.A., et al.

**摘要**: 研究通過(guò)Western blot和免疫熒光技術(shù),利用特異性ADRA1B抗體分析了腎上腺素受體α1B亞型在細(xì)胞膜上的分布及其磷酸化調(diào)控機(jī)制,揭示其在G蛋白偶聯(lián)受體信號(hào)轉(zhuǎn)導(dǎo)中的動(dòng)態(tài)變化。

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2. **文獻(xiàn)名稱**: "ADRA1B modulates cancer cell proliferation via PKC/MAPK pathways"

**作者**: Zhao, Y., et al.

**摘要**: 該研究使用ADRA1B特異性抗體進(jìn)行免疫組化和流式細(xì)胞術(shù),發(fā)現(xiàn)ADRA1B在多種癌細(xì)胞系中高表達(dá),并通過(guò)激活PKC和MAPK通路促進(jìn)腫瘤細(xì)胞增殖,提示其作為潛在治療靶點(diǎn)。

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3. **文獻(xiàn)名稱**: "Tissue-specific expression of α1-adrenergic receptor subtypes"

**作者**: Michelotti, G.A., et al.

**摘要**: 通過(guò)比較不同組織(如心臟、肝臟、腦)中α1腎上腺素受體亞型的表達(dá)差異,利用ADRA1B抗體進(jìn)行免疫印跡分析,證實(shí)ADRA1B在中樞神經(jīng)系統(tǒng)和血管平滑肌中的高表達(dá)及其生理意義。

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4. **文獻(xiàn)名稱**: "Targeted deletion of ADRA1B alters behavioral responses to stress"

**作者**: Tanoue, A., et al.

**摘要**: 研究通過(guò)ADRA1B基因敲除小鼠模型,結(jié)合抗體驗(yàn)證蛋白表達(dá)缺失,發(fā)現(xiàn)ADRA1B缺失導(dǎo)致小鼠對(duì)急性應(yīng)激的行為反應(yīng)異常,表明其在交感神經(jīng)應(yīng)激調(diào)控中的關(guān)鍵作用。

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建議通過(guò)PubMed或Google Scholar輸入關(guān)鍵詞(如“ADRA1B antibody”、“alpha1B-adrenergic receptor”)獲取原文核實(shí)。

       

背景信息

The ADRA1B antibody targets the alpha-1B-adrenergic receptor (ADRA1B), a G protein-coupled receptor (GPCR) primarily activated by catecholamines like epinephrine and norepinephrine. ADRA1B is one of three subtypes (ADRA1A, ADRA1B, ADRA1D) within the alpha-1-adrenergic receptor family, which mediates physiological responses such as vasoconstriction, smooth muscle contraction, and modulation of neurotransmission. This receptor is predominantly expressed in the brain, liver, kidneys, and vascular smooth muscle, playing a role in regulating blood pressure, metabolic processes, and central nervous system functions.

ADRA1B antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both normal and pathological conditions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ADRA1B's involvement in diseases such as hypertension, benign prostatic hyperplasia, and neurological disorders. Researchers also utilize these antibodies to explore receptor dynamics, including ligand binding, internalization, and interactions with downstream effectors.

Commercial ADRA1B antibodies are typically raised in hosts like rabbits or mice, with validation methods including knockout cell lines or tissues to confirm specificity. Challenges in antibody development arise from the structural homology among adrenergic receptor subtypes, necessitating rigorous cross-reactivity testing. Understanding ADRA1B's role through antibody-based research contributes to therapeutic advancements, particularly in designing subtype-selective drugs with minimized side effects.

       
關(guān)鍵字: ADRA1B抗體;ADRA1B;ADRA1B Antibody;

公司簡(jiǎn)介

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VIP 1年
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  • 主營(yíng)產(chǎn)品:中間體。試劑
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詢盤

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ADRA1B抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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