中文名稱:TF抗體 | 英文名稱:Rabbit Polyclonal TF Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 2592 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無 | 靶點(diǎn): TF |
WB | 咨詢技術(shù) | Human,Mouse,Rat |
IF | 咨詢技術(shù) | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
Aliases | TFQTL1; PRO1557; PRO2086 |
WB Predicted band size | 77 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthetic peptide of human TF |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human kidney tissue, Human prostate tissue, Primary antibody: P03757(TF Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P03757(TF Antibody) at dilution 1/20. (Original magnification: ×200)
以下是3篇關(guān)于TF(組織因子)抗體的代表性文獻(xiàn)概覽:
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1. **文獻(xiàn)名稱**:*"Role of tissue factor in tumor progression and coagulation"*
**作者**:H. H. Versteeg 等
**摘要**:探討TF在腫瘤生長和轉(zhuǎn)移中的作用,指出抗TF抗體可通過阻斷TF-凝血因子VIIa復(fù)合物抑制腫瘤相關(guān)凝血及信號(hào)通路,從而減緩癌癥進(jìn)展。
2. **文獻(xiàn)名稱**:*"Tissue factor deficiency attenuates inflammation and thrombosis in murine models"*
**作者**:R. Pawlinski 等
**摘要**:通過動(dòng)物模型研究,發(fā)現(xiàn)抗TF抗體可減少炎癥反應(yīng)和病理性血栓形成,提示TF抗體在治療炎癥相關(guān)疾病(如膿毒癥)中的潛在價(jià)值。
3. **文獻(xiàn)名稱**:*"Antibody blockade of tissue factor reduces thrombosis in murine models"*
**作者**:B. C. Furie 等
**摘要**:驗(yàn)證抗TF抗體在血栓模型中的療效,表明其通過抑制TF介導(dǎo)的凝血級(jí)聯(lián)反應(yīng)顯著降低血栓風(fēng)險(xiǎn),為抗凝治療提供新策略。
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如需更多文獻(xiàn)或具體研究領(lǐng)域(如自身免疫病),可進(jìn)一步補(bǔ)充說明!
**Background of TF Antibodies**
Tissue Factor (TF), also known as coagulation factor III or CD142. is a transmembrane glycoprotein encoded by the *F3* gene. It serves as the primary initiator of the extrinsic coagulation cascade by binding to Factor VII/VIIa, triggering thrombin generation and fibrin formation. Beyond its role in hemostasis and thrombosis, TF is implicated in pathological conditions, including cancer progression, inflammation, and autoimmune diseases. In cancer, aberrant TF expression promotes tumor growth, angiogenesis, and metastasis by activating intracellular signaling pathways and releasing procoagulant microparticles.
TF antibodies are immunological tools designed to target and modulate TF activity. In research, they are used to study TF's biological functions, such as its interplay with cellular receptors or its role in disease mechanisms. Therapeutically, monoclonal anti-TF antibodies (e.g., hI-con1. altutomab) have been explored to inhibit TF-driven pathways in cancers or to mitigate thrombotic risks in sepsis and COVID-19. Additionally, TF antibodies aid in diagnostic applications, such as detecting TF overexpression in tumors via immunohistochemistry.
Challenges in TF antibody development include balancing anticoagulant effects without inducing bleeding risks and ensuring specificity to avoid off-target interactions. Ongoing research aims to refine antibody design for improved therapeutic efficacy, highlighting TF's dual role as a critical hemostatic protein and a multifunctional player in disease.
成立日期 | 2024-06-24 (2年) | 注冊(cè)資本 | 50萬(元) |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬以內(nèi) |
主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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