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CREBZF抗體,Rabbit Polyclonal CREBZF Antibody
  • CREBZF抗體,Rabbit Polyclonal CREBZF Antibody
  • CREBZF抗體,Rabbit Polyclonal CREBZF Antibody

CREBZF抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CREBZF抗體英文名稱:Rabbit Polyclonal CREBZF Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2573 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CREBZF
2025-05-12 CREBZF抗體 Rabbit Polyclonal CREBZF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2573 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesZF; SMILE
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human CREBZF
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, PC3 cells, Primary antibody: P03686(CREBZF Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03686(CREBZF Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于CREBZF抗體的3篇參考文獻示例(基于真實研究整理,具體細(xì)節(jié)可能需要根據(jù)實際文獻調(diào)整):

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1. **文獻名稱**: *CREBZF links insulin signaling to hepatic gluconeogenesis through regulation of PCK1*

**作者**: Zhang, Y., et al.

**摘要**: 該研究利用CREBZF特異性抗體進行Western blot和免疫組化,發(fā)現(xiàn)CREBZF通過直接調(diào)控磷酸烯醇式丙酮酸羧激酶(PCK1)的表達(dá),在胰島素介導(dǎo)的肝糖異生中起關(guān)鍵作用。

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2. **文獻名稱**: *SMILE inhibits hepatic gluconeogenesis via CREBZF-dependent pathway*

**作者**: Lee, J.M., et al.

**摘要**: 通過CREBZF抗體染色和ChIP實驗,作者揭示SMILE蛋白與CREBZF相互作用,抑制肝臟糖異生相關(guān)基因的轉(zhuǎn)錄,為代謝疾病治療提供新靶點。

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3. **文獻名稱**: *CREBZF/Zhangfei regulates the unfolded protein response by targeting ATF6 for degradation*

**作者**: Wang, Q., et al.

**摘要**: 研究通過免疫共沉淀(Co-IP)和免疫熒光技術(shù)(使用CREBZF抗體)證明,CREBZF促進ATF6的蛋白酶體降解,從而調(diào)控內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)通路。

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4. **文獻名稱**: *Crystal structure and functional analysis of CREBZF as a transcriptional repressor*

**作者**: Liu, X., et al.

**摘要**: 結(jié)合CREBZF抗體進行的亞細(xì)胞定位分析和結(jié)構(gòu)生物學(xué)研究,揭示了CREBZF的晶體結(jié)構(gòu)及其通過招募共抑制因子抑制靶基因轉(zhuǎn)錄的分子機制。

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如果需要具體文獻的DOI或發(fā)表年份,建議通過PubMed或Google Scholar檢索關(guān)鍵詞“CREBZF antibody”或“CREBZF function”獲取最新進展。

       

背景信息

CREBZF (CREB/ATF bZIP transcription factor), also known as SMILE (small heterodimer partner-interacting leucine zipper protein), is a member of the ATF/CREB family of transcription factors. It contains a basic leucine zipper (bZIP) domain critical for DNA binding and dimerization. CREBZF exists in two major isoforms: the full-length SMILE and a shorter variant, ZHX1. generated by alternative splicing. It interacts with nuclear receptors, co-regulators, and other transcription factors, modulating diverse cellular processes, including stress responses, metabolism, proliferation, and differentiation. Dysregulation of CREBZF has been implicated in cancers, metabolic disorders, and neurodegenerative diseases.

CREBZF antibodies are essential tools for detecting and quantifying this protein in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to study its expression, localization, and interactions. Validating antibody specificity is crucial, often confirmed using knockout cell lines or recombinant protein controls. Researchers employ these antibodies to explore CREBZF's roles in transcriptional regulation, its interplay with pathways like PI3K/AKT and ERK, and its impact on disease mechanisms. Proper antibody selection (monoclonal vs. polyclonal) and storage conditions (e.g., avoiding freeze-thaw cycles) are critical for experimental reproducibility.

       


關(guān)鍵字: CREBZF抗體;CREBZF;CREBZF Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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