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SERPINB4抗體,Rabbit Polyclonal SERPINB4 Antibody
  • SERPINB4抗體,Rabbit Polyclonal SERPINB4 Antibody
  • SERPINB4抗體,Rabbit Polyclonal SERPINB4 Antibody
  • SERPINB4抗體,Rabbit Polyclonal SERPINB4 Antibody

SERPINB4抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產品詳情

中文名稱:SERPINB4抗體英文名稱:Rabbit Polyclonal SERPINB4 Antibody
品牌: 艾普蒂產地: 武漢
保存條件: Stored at -20°C for 2062 year. Avoid repeated freeze / thaw cycles.產品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: SERPINB4
2025-05-11 SERPINB4抗體 Rabbit Polyclonal SERPINB4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2062 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產品詳情

AliasesPI11; SCCA1; SCCA2; LEUPIN; SCCA-2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human SERPINB4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P01787(SERPINB4 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻

以下是關于SERPINB4抗體的3篇參考文獻示例(內容為模擬概括,僅供參考):

1. **文獻名稱**:*SERPINB4 as a prognostic biomarker in cutaneous squamous cell carcinoma*

**作者**:Scott LM, et al. (2019)

**摘要**:研究通過免疫組化(使用SERPINB4特異性抗體)發(fā)現(xiàn),SERPINB4在皮膚鱗癌組織中高表達,并與患者不良預后相關,提示其可能作為潛在治療靶點。

2. **文獻名稱**:*Role of SERPINB4 in modulating allergic inflammation*

**作者**:Tanaka H, et al. (2020)

**摘要**:利用抗SERPINB4抗體進行功能阻斷實驗,發(fā)現(xiàn)SERPINB4通過抑制蛋白酶活性加劇Th2型炎癥反應,與過敏性皮炎發(fā)病機制相關。

3. **文獻名稱**:*SERPINB4 antibody-based detection in psoriatic skin lesions*

**作者**:Johnson R, et al. (2018)

**摘要**:通過Western blot和免疫熒光(使用SERPINB4抗體)證實銀屑病皮損中SERPINB4表達顯著上調,可能與表皮屏障功能障礙有關。

4. **文獻名稱**:*SERPINB4 promotes tumor immune evasion via antibody-mediated pathway analysis*

**作者**:Lee S, et al. (2021)

**摘要**:研究采用抗SERPINB4抗體揭示其在腫瘤微環(huán)境中抑制T細胞活性,提示靶向SERPINB4可能增強免疫治療響應。

(注:以上文獻信息為示例,實際引用請以真實數(shù)據(jù)庫檢索結果為準。)

       

背景信息

SERPINB4. a member of the serine protease inhibitor (serpin) superfamily, is encoded by the SERPINB4 gene located on chromosome 18q21.3. It is also known as squamous cell carcinoma antigen 2 (SCCA2) and shares structural homology with SERPINB3 (SCCA1), both clustered in the same genomic region. Primarily expressed in squamous epithelial cells, SERPINB4 inhibits proteases like kallikreins and cathepsins, playing roles in immune regulation, inflammation, and tissue remodeling. Dysregulation of SERPINB4 is linked to squamous cell carcinomas (e.g., cervical, lung, head/neck cancers), where its overexpression correlates with tumor progression, metastasis, and apoptosis resistance. It is also implicated in inflammatory skin disorders such as psoriasis and atopic dermatitis, contributing to abnormal keratinocyte differentiation and immune activation.

SERPINB4 antibodies are critical tools for detecting this protein in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study SERPINB4 expression patterns in tissues or biofluids. These antibodies aid in exploring its role as a biomarker for cancer prognosis or therapeutic targeting. However, challenges include potential cross-reactivity with SERPINB3 due to high sequence similarity, necessitating rigorous validation. Ongoing research focuses on clarifying SERPINB4’s dual roles in tumorigenesis and inflammation, as well as its potential as a diagnostic or immunotherapeutic target in precision medicine.

       
關鍵字: SERPINB4抗體;SERPINB4;SERPINB4 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質量管理體系。并不斷致力于技術創(chuàng)新,產品創(chuàng)新和管理創(chuàng)新,贏得了國內外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產品:中間體。試劑
  • 公司地址:江漢區(qū)
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