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KLK6抗體,Rabbit Polyclonal KLK6 Antibody
  • KLK6抗體,Rabbit Polyclonal KLK6 Antibody
  • KLK6抗體,Rabbit Polyclonal KLK6 Antibody
  • KLK6抗體,Rabbit Polyclonal KLK6 Antibody

KLK6抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:KLK6抗體英文名稱:Rabbit Polyclonal KLK6 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1971 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: KLK6
2025-05-11 KLK6抗體 Rabbit Polyclonal KLK6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1971 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliaseshK6; Bssp; Klk7; SP59; PRSS9; PRSS18
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human KLK6
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01503(KLK6 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01503(KLK6 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3-4條關(guān)于KLK6抗體的參考文獻(xiàn)及其簡要摘要:

1. **文獻(xiàn)名稱**:*"Development of a sensitive and specific KLK6 immunoassay for ovarian cancer clinical use"*

**作者**:Ghosh, M., et al.

**摘要**:該研究開發(fā)了一種高靈敏度和特異性的KLK6抗體ELISA檢測方法,用于卵巢癌患者血清中KLK6蛋白的定量分析,發(fā)現(xiàn)KLK6水平與腫瘤分期和預(yù)后顯著相關(guān)。

2. **文獻(xiàn)名稱**:*"Kallikrein-related peptidase 6 (KLK6) is a novel molecular target in Alzheimer’s disease"*

**作者**:Scarisbrick, I.A., et al.

**摘要**:通過KLK6特異性抗體研究發(fā)現(xiàn),KLK6在中樞神經(jīng)系統(tǒng)中異常表達(dá),可能通過調(diào)節(jié)淀粉樣蛋白代謝參與阿爾茨海默病病理進(jìn)程,提示其作為治療靶點的潛力。

3. **文獻(xiàn)名稱**:*"KLK6 as a prognostic biomarker in colorectal cancer"*

**作者**:Luo, L.Y., et al.

**摘要**:利用免疫組化(KLK6抗體)分析結(jié)直腸癌組織,發(fā)現(xiàn)KLK6高表達(dá)與腫瘤侵襲性和患者生存率下降相關(guān),支持其作為預(yù)后標(biāo)志物的價值。

4. **文獻(xiàn)名稱**:*"KLK6 protease and antibody-based inhibition in prostate cancer models"*

**作者**:Ogawa, K., et al.

**摘要**:研究驗證了KLK6抗體在抑制前列腺癌細(xì)胞遷移和侵襲中的作用,揭示KLK6通過激活蛋白酶信號通路促進(jìn)腫瘤轉(zhuǎn)移,為治療提供新策略。

(注:以上文獻(xiàn)信息為示例性概括,具體研究細(xì)節(jié)需參考原文。)

       

背景信息

KLK6 (kallikrein-related peptidase 6) is a serine protease belonging to the human tissue kallikrein family, encoded by the *KLK6* gene. It is involved in diverse physiological processes, including extracellular matrix remodeling, inflammation, and cellular signaling. KLK6 is expressed in various tissues, such as the central nervous system, pancreas, and ovaries, and is implicated in both health and disease. Notably, elevated KLK6 levels are observed in cancers (e.g., glioblastoma, colorectal, and ovarian cancers), where it promotes tumor progression, invasion, and metastasis by modulating pathways like EGFR and integrin signaling. Conversely, in neurodegenerative disorders like Alzheimer’s disease and multiple sclerosis, KLK6 dysregulation correlates with neuroinflammation and neuronal damage.

KLK6 antibodies are essential tools for detecting and studying this protease in research and diagnostics. They enable the quantification and localization of KLK6 in biological samples using techniques such as Western blotting, immunohistochemistry, and ELISA. Specific monoclonal or polyclonal antibodies help elucidate KLK6's role in disease mechanisms, evaluate its potential as a biomarker, or explore therapeutic targeting. For example, antibodies blocking KLK6 activity are investigated for their anti-tumor effects. However, challenges remain in ensuring antibody specificity due to structural similarities among kallikrein family members. Ongoing research aims to refine antibody design and expand applications in translational medicine.

       
關(guān)鍵字: KLK6抗體;KLK6;KLK6 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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