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FXYD1抗體,Rabbit Polyclonal FXYD1 Antibody
  • FXYD1抗體,Rabbit Polyclonal FXYD1 Antibody
  • FXYD1抗體,Rabbit Polyclonal FXYD1 Antibody
  • FXYD1抗體,Rabbit Polyclonal FXYD1 Antibody

FXYD1抗體

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
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產(chǎn)品詳情

中文名稱(chēng):FXYD1抗體英文名稱(chēng):Rabbit Polyclonal FXYD1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1850 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): FXYD1
2025-05-11 FXYD1抗體 Rabbit Polyclonal FXYD1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1850 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢(xún)技術(shù) Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM咨詢(xún)技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesPLM
WB Predicted band size10 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human FXYD1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, Mouse heart tissue, Primary antibody: P01079(FXYD1 Antibody) at dilution 1/1290, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P01079(FXYD1 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01079(FXYD1 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于FXYD1抗體的3篇示例文獻(xiàn)(注:以下為模擬示例,具體文獻(xiàn)需根據(jù)實(shí)際數(shù)據(jù)庫(kù)檢索確認(rèn)):

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1. **文獻(xiàn)名稱(chēng)**:*"A Monoclonal Antibody Targeting FXYD1 Reveals Dynamic Localization in Cardiac Myocytes"*

**作者**:Chen L, et al.

**摘要**:本研究開(kāi)發(fā)了一種特異性識(shí)別FXYD1的單克隆抗體,通過(guò)免疫熒光和Western blot驗(yàn)證其在心肌細(xì)胞中的動(dòng)態(tài)定位,發(fā)現(xiàn)其在缺血再灌注損傷后表達(dá)顯著上調(diào),提示其與心臟應(yīng)激反應(yīng)的關(guān)聯(lián)。

2. **文獻(xiàn)名稱(chēng)**:*"Phosphorylation-Specific Antibodies for FXYD1 Elucidate Its Role in Sodium Pump Regulation"*

**作者**:Kumar R, et al.

**摘要**:利用針對(duì)FXYD1不同磷酸化位點(diǎn)的抗體,揭示了其在調(diào)節(jié)鈉鉀ATP酶活性中的分子機(jī)制,證明Ser68磷酸化是響應(yīng)β-腎上腺素信號(hào)的關(guān)鍵修飾位點(diǎn)。

3. **文獻(xiàn)名稱(chēng)**:*"FXYD1 as a Biomarker in Colorectal Cancer: Validation by Immunohistochemical Analysis"*

**作者**:Garcia S, et al.

**摘要**:通過(guò)多克隆抗體進(jìn)行組織免疫組化分析,發(fā)現(xiàn)FXYD1在結(jié)直腸癌中高表達(dá)且與患者預(yù)后不良相關(guān),支持其作為潛在治療靶點(diǎn)的可能性。

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**提示**:實(shí)際引用時(shí)建議通過(guò)PubMed或Google Scholar檢索最新文獻(xiàn),使用關(guān)鍵詞“FXYD1 antibody”、“phospholemman antibody”或結(jié)合研究領(lǐng)域(如“FXYD1 cancer”)。部分經(jīng)典文獻(xiàn)可能涉及抗體開(kāi)發(fā)或功能驗(yàn)證,例如:

- **FXYD1抗體開(kāi)發(fā)**:*J Biol Chem* (2003) 上的早期研究。

- **疾病機(jī)制**:涉及心臟或腫瘤的文獻(xiàn)(如*Circ Res*或*Oncogene*期刊)。

       

背景信息

**Background of FXYD1 Antibodies**

FXYD1. also known as phospholemman, is a small transmembrane protein that regulates the activity of the Na+/K+-ATPase pump, a critical enzyme responsible for maintaining cellular ion gradients. It belongs to the FXYD protein family, which modulates ion transport in a tissue-specific manner. FXYD1 is highly expressed in the heart, skeletal muscle, and brain, where it fine-tunes sodium and potassium ion flux, impacting cellular excitability and osmotic balance. Its activity is further influenced by post-translational modifications, such as phosphorylation, which alter its interaction with the Na+/K+-ATPase.

Antibodies targeting FXYD1 are essential tools for studying its expression, localization, and functional roles in physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess FXYD1 protein levels and distribution in tissues or cells. Researchers employ FXYD1-specific antibodies to investigate its involvement in diseases such as heart failure (where FXYD1 dysregulation affects cardiac contractility), cancer (linked to ion homeostasis and cell proliferation), and metabolic disorders. Both monoclonal and polyclonal FXYD1 antibodies are available, with validation including knockout controls or peptide-blocking assays to confirm specificity. Understanding FXYD1's role through antibody-based research continues to shed light on its regulatory mechanisms and therapeutic potential.

       
關(guān)鍵字: FXYD1抗體;FXYD1;FXYD1 Antibody;

公司簡(jiǎn)介

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產(chǎn)品名稱(chēng) 價(jià)格   公司名稱(chēng) 報(bào)價(jià)日期
詢(xún)價(jià)
VIP3年
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¥1800
VIP1年
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2025-07-28
詢(xún)價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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