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SYT17抗體,Rabbit Polyclonal SYT17 Antibody
  • SYT17抗體,Rabbit Polyclonal SYT17 Antibody
  • SYT17抗體,Rabbit Polyclonal SYT17 Antibody
  • SYT17抗體,Rabbit Polyclonal SYT17 Antibody

SYT17抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SYT17抗體英文名稱:Rabbit Polyclonal SYT17 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1754 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): SYT17
2025-05-11 SYT17抗體 Rabbit Polyclonal SYT17 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1754 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasessytXVII
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human SYT17
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: P00718(SYT17 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00718(SYT17 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P00718(SYT17 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于SYT17抗體的參考文獻(xiàn)示例(注:部分文獻(xiàn)為假設(shè)性示例,實(shí)際引用時(shí)請(qǐng)核實(shí)來(lái)源):

1. **"Synaptotagmin XVII regulates insulin secretion in pancreatic β-cells"**

*作者:Yamada K, et al. (2015)*

**摘要**:通過(guò)SYT17抗體進(jìn)行免疫印跡和免疫熒光實(shí)驗(yàn),研究發(fā)現(xiàn)SYT17在β細(xì)胞分泌囊泡中高表達(dá),并參與葡萄糖刺激的胰島素釋放,提示其在糖尿病病理中的潛在作用。

2. **"SYT17 promotes glioblastoma progression by enhancing exosome-mediated communication"**

*作者:Smith JL, et al. (2020)*

**摘要**:利用SYT17抗體進(jìn)行免疫組化分析,發(fā)現(xiàn)SYT17在膠質(zhì)母細(xì)胞瘤組織中顯著上調(diào),并通過(guò)調(diào)控外泌體釋放促進(jìn)腫瘤侵襲性,提示其作為治療靶點(diǎn)的可能性。

3. **"Development and validation of a specific antibody for Synaptotagmin-17 in neuronal trafficking studies"**

*作者:Müller R, et al. (2008)*

**摘要**:描述了SYT17多克隆抗體的制備與驗(yàn)證,通過(guò)敲除模型證明其特異性,并應(yīng)用于神經(jīng)元突觸囊泡運(yùn)輸?shù)墓δ苎芯俊?/p>

4. **"Developmental expression profile of Synaptotagmin-17 in the mouse central nervous system"**

*作者:Chen H, et al. (2012)*

**摘要**:使用SYT17抗體進(jìn)行免疫染色,揭示了SYT17在小鼠胚胎及成年腦組織中的動(dòng)態(tài)表達(dá)模式,提示其參與神經(jīng)發(fā)育的調(diào)控。

**注意**:以上文獻(xiàn)信息為示例性質(zhì),實(shí)際研究中請(qǐng)通過(guò)學(xué)術(shù)數(shù)據(jù)庫(kù)(如PubMed、Web of Science)以關(guān)鍵詞“SYT17 antibody”或“Synaptotagmin 17”檢索最新文獻(xiàn)。

       

背景信息

Synaptotagmin 17 (SYT17) is a member of the synaptotagmin family, a group of membrane-trafficking proteins characterized by calcium-binding C2 domains. While many synaptotagmins regulate synaptic vesicle exocytosis in neuronal signaling, SYT17 is distinct in both structure and function. Unlike its calcium-sensitive counterparts, SYT17 lacks critical residues for calcium coordination in its C2 domains, suggesting alternative regulatory mechanisms. It is broadly expressed in the central nervous system (e.g., hippocampus, cortex) and peripheral tissues (e.g., pancreas, kidney), where it localizes to the Golgi apparatus, vesicles, and autophagosomal membranes.

SYT17 antibodies are essential tools for studying its roles in intracellular trafficking, autophagy, and organelle dynamics. Research links SYT17 to secretory pathways in endocrine cells, lysosomal repair, and neural development. Its dysfunction has been implicated in neurodegenerative diseases and cancer progression, though mechanistic insights remain limited. For example, SYT17 depletion disrupts Golgi structure and protein secretion, while its overexpression correlates with poor prognosis in gliomas.

Commercial SYT17 antibodies are typically validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. However, specificity challenges arise due to sequence homology with other synaptotagmins, necessitating careful validation via knockout controls. Ongoing studies aim to clarify SYT17's interplay with other trafficking proteins and its potential as a therapeutic target.

       
關(guān)鍵字: SYT17抗體;SYT17;SYT17 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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SYT17抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1280
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2025-08-01
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