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UGCG抗體,Rabbit Polyclonal UGCG Antibody
  • UGCG抗體,Rabbit Polyclonal UGCG Antibody
  • UGCG抗體,Rabbit Polyclonal UGCG Antibody
  • UGCG抗體,Rabbit Polyclonal UGCG Antibody

UGCG抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:UGCG抗體英文名稱:Rabbit Polyclonal UGCG Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1689 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: UGCG
2025-05-11 UGCG抗體 Rabbit Polyclonal UGCG Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1689 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGCS; GLCT1
WB Predicted band size45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human UGCG
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, MCF7, A375 cell lysates, Primary antibody: P00397(UGCG Antibody) at dilution 1/1350, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00397(UGCG Antibody) at dilution 1/95. (Original magnification: ×200)    


           

參考文獻

以下是3篇涉及UGCG抗體的相關(guān)文獻摘要(基于公開研究整理,部分為虛構(gòu)示例供參考):

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1. **"UGCG knockdown inhibits glioblastoma growth through ceramide accumulation"**

*作者:Smith A, et al. (2020)*

*摘要:* 本研究利用UGCG特異性抗體(貨號ABX-123)通過Western blot驗證了shRNA敲低UGCG在膠質(zhì)母細(xì)胞瘤細(xì)胞中的效率,發(fā)現(xiàn)抑制UGCG導(dǎo)致神經(jīng)酰胺水平上升并誘導(dǎo)腫瘤細(xì)胞凋亡。

2. **"Anti-UGCG monoclonal antibody blocks glycosphingolipid synthesis in Gaucher disease models"**

*作者:Chen L, et al. (2018)*

*摘要:* 開發(fā)了一種靶向UGCG的單克隆抗體(克隆號mAb-5C2),通過免疫熒光和流式細(xì)胞術(shù)證實其可抑制UGCG酶活性,減少葡糖神經(jīng)酰胺合成,為戈謝病治療提供新策略。

3. **"UGCG overexpression promotes chemoresistance via antibody-based detection in colorectal cancer"**

*作者:Wang Y, et al. (2022)*

*摘要:* 使用兔源多克隆UGCG抗體(Sigma-Aldrich HPA042772)進行免疫組化分析,發(fā)現(xiàn)結(jié)直腸癌中UGCG高表達與奧沙利鉑耐藥性相關(guān),機制涉及鞘脂代謝重編程。

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注:以上文獻為示例性質(zhì),實際引用需以真實數(shù)據(jù)庫(如PubMed)檢索結(jié)果為準(zhǔn)。建議通過關(guān)鍵詞“UGCG antibody”、“glucosylceramide synthase”等結(jié)合實驗方法(如Western blot/IHC)篩選目標(biāo)文獻。

       

背景信息

The UDP-glucose ceramide glucosyltransferase (UGCG) antibody is a crucial tool for studying the enzyme UGCG, a key regulator in glycosphingolipid (GSL) biosynthesis. UGCG catalyzes the transfer of glucose to ceramide, forming glucosylceramide (GlcCer), the foundational step in GSL synthesis. These lipids are essential components of cell membranes, influencing signal transduction, cell adhesion, and membrane trafficking. Dysregulation of UGCG activity is linked to pathological conditions, including cancer, neurodegenerative diseases, and lysosomal storage disorders like Gaucher’s disease.

In cancer research, UGCG overexpression is associated with multidrug resistance and tumor progression, as GSLs modulate survival pathways and drug efflux mechanisms. UGCG antibodies enable detection of enzyme expression levels in tissues or cell lines, aiding mechanistic studies. In neuroscience, altered GSL metabolism due to UGCG dysfunction is implicated in Parkinson’s and Alzheimer’s diseases. Additionally, UGCG inhibitors are explored as therapeutic agents, necessitating precise antibody-based quantification in preclinical models.

UGCG antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Their specificity is validated via knockout controls or enzymatic assays. Research also focuses on UGCG’s role in viral entry mechanisms, as certain viruses exploit GSL-rich membrane domains for infection. Understanding UGCG’s biological and pathological roles underscores the antibody’s importance in both basic science and translational applications.

       
關(guān)鍵字: UGCG抗體;UGCG;UGCG Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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