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BUB1抗體,Mouse Monoclonal BUB1 Antibody
  • BUB1抗體,Mouse Monoclonal BUB1 Antibody
  • BUB1抗體,Mouse Monoclonal BUB1 Antibody
  • BUB1抗體,Mouse Monoclonal BUB1 Antibody

BUB1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BUB1抗體英文名稱:Mouse Monoclonal BUB1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 895 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: BUB1
2025-05-10 BUB1抗體 Mouse Monoclonal BUB1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 895 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMediator of RNA polymerase II transcription subunit 16, Mediator complex subunit 16, Thyroid hormone receptor-associated protein 5, Thyroid hormone receptor-associated protein complex 95 kDa component, Trap95, Vitamin D3 receptor-interacting protein complex 92 kDa component, DRIP92, MED16, DRIP92 {ECO:0000312|EMBL:AAD310871}, THRAP5
Entrez GeneID10025
WB Predicted band size96.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MED16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the Central region of human MED16.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       MED16 Antibody (Center) (Cat. #P31678) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MED16 antibody detected the MED16 protein (arrow).    


           

參考文獻

以下是關(guān)于BUB1抗體的3篇參考文獻及其簡要概括:

1. **"BUB1 is essential for the kinetochore localization of Mad1 and Mad2 in human cells"**

- **作者**: Taylor, S.S., McKeon, F.

- **摘要**: 研究利用BUB1抗體驗證其在人類細胞中的定位,發(fā)現(xiàn)BUB1對Mad1/Mad2復(fù)合物在動粒上的招募至關(guān)重要,揭示了其在紡錘體檢查點調(diào)控中的作用。

2. **"Phosphorylation of the CPC subunit Cdc20 by BUB1 facilitates mitotic checkpoint signaling"**

- **作者**: Kitagawa, R., Yu, J.

- **摘要**: 通過BUB1抗體阻斷實驗,發(fā)現(xiàn)BUB1通過磷酸化Cdc20調(diào)控染色體正確分離,強調(diào)其酶活性在維持基因組穩(wěn)定性中的關(guān)鍵性。

3. **"BUB1 and BUBR1 regulate kinetochore attachment by sensing tension via Aurora B"**

- **作者**: Lischetti, T., Nilsson, J.

- **摘要**: 使用BUB1抗體研究其與Aurora B激酶的相互作用,提出BUB1通過感知張力調(diào)控動粒-微管附著的糾錯機制,完善了紡錘體檢查點模型。

注:以上文獻為示例性概括,具體內(nèi)容需參考原文。實際引用時建議通過PubMed等數(shù)據(jù)庫核對作者及期刊信息。

       

背景信息

BUB1 (Budding Uninhibited by Benzimidazoles 1) is a serine/threonine kinase crucial for the spindle assembly checkpoint (SAC), a surveillance mechanism ensuring accurate chromosome segregation during mitosis. It localizes to kinetochores and plays dual roles: recruiting other SAC components (e.g., BUBR1. CDC20) to delay anaphase until chromosomes achieve proper microtubule attachment, and promoting chromosome alignment through Aurora B kinase regulation. Dysregulation of BUB1 is linked to chromosomal instability, aneuploidy, and cancer progression.

BUB1 antibodies are essential tools for studying mitotic checkpoint mechanisms, protein localization, and expression levels in cell cycle research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect BUB1 in human, mouse, or other model organisms. Commercial antibodies often target conserved regions, such as the N-terminal or kinase domains. Validation includes testing in knockout cell lines or siRNA-treated samples to confirm specificity.

Research applications include investigating BUB1's role in cancer (e.g., overexpression in tumors correlates with poor prognosis), its interaction with tumor suppressors like p53. and its potential as a therapeutic target. Some studies also explore BUB1 inhibitors to sensitize cancer cells to chemotherapy. Proper antibody selection and validation are critical due to cross-reactivity risks with homologous proteins (e.g., BUBR1).

       
關(guān)鍵字: BUB1抗體;BUB1;BUB1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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