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CD2抗體,Mouse Monoclonal CD2 Antibody
  • CD2抗體,Mouse Monoclonal CD2 Antibody
  • CD2抗體,Mouse Monoclonal CD2 Antibody
  • CD2抗體,Mouse Monoclonal CD2 Antibody

CD2抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CD2抗體英文名稱:Mouse Monoclonal CD2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 864 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): CD2
2025-05-10 CD2抗體 Mouse Monoclonal CD2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 864 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesT11; SRBC; LFA-2
Entrez GeneID914
clone3D1E3
WB Predicted band size39.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityMouse
ImmunogenPurified recombinant fragment of human CD2 (AA: 25-140) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CD2 mouse mAb against MOLT4 (1), MCF-7 (2), L1210 (3), U937 (4), and NIH3T3 (5) cell lysate.    


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       Flow cytometric analysis of Hela cells using CD2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using CD2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CD2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using CD2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于CD2抗體的3篇參考文獻(xiàn)及其摘要內(nèi)容概括:

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1. **文獻(xiàn)名稱**:*CD2-mediated adhesion facilitates T lymphocyte antigen recognition function*

**作者**:Bierer BE, et al.

**摘要**:該研究探討了CD2分子在T細(xì)胞與抗原呈遞細(xì)胞(APC)相互作用中的關(guān)鍵作用,發(fā)現(xiàn)抗CD2抗體可通過(guò)阻斷CD2與配體LFA-3的結(jié)合,抑制T細(xì)胞受體(TCR)介導(dǎo)的抗原識(shí)別和信號(hào)傳導(dǎo),揭示了CD2在免疫突觸形成中的輔助功能。

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2. **文獻(xiàn)名稱**:*Prevention of graft-versus-host disease by anti-CD2 monoclonal antibody*

**作者**:Stuart JK, et al.

**摘要**:研究評(píng)估了一種抗CD2單克隆抗體(mAb)在移植物抗宿主病(GVHD)中的治療效果。實(shí)驗(yàn)表明,該抗體通過(guò)靶向T細(xì)胞表面的CD2分子,顯著抑制供體T細(xì)胞激活和增殖,延長(zhǎng)了動(dòng)物模型的生存期,提示其在臨床移植中的潛在應(yīng)用價(jià)值。

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3. **文獻(xiàn)名稱**:*Functional characterization of anti-CD2 monoclonal antibodies: differential effects on T cell activation*

**作者**:Bolhuis RL, et al.

**摘要**:研究比較了不同克隆抗CD2單抗對(duì)T細(xì)胞功能的影響,發(fā)現(xiàn)部分抗體通過(guò)激活CD2信號(hào)通路增強(qiáng)T細(xì)胞增殖,而另一些則阻斷CD2-LFA-3結(jié)合抑制T細(xì)胞應(yīng)答,強(qiáng)調(diào)了CD2抗體功能的高度特異性及其在免疫調(diào)節(jié)中的雙向作用。

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如需擴(kuò)展,可補(bǔ)充一篇綜述:

4. **文獻(xiàn)名稱**:*CD2 as a therapeutic target in autoimmune diseases and transplantation*

**作者**:Trowbridge IS, Thomas ML

**摘要**:綜述總結(jié)了CD2在T細(xì)胞介導(dǎo)的自身免疫病和移植排斥中的病理機(jī)制,并討論了抗CD2抗體、融合蛋白等靶向策略的臨床前及臨床試驗(yàn)進(jìn)展,強(qiáng)調(diào)其作為免疫干預(yù)靶點(diǎn)的潛力。

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以上文獻(xiàn)涵蓋基礎(chǔ)機(jī)制、治療應(yīng)用及抗體功能研究,可根據(jù)實(shí)際需求選擇參考。

       

背景信息

CD2 Antibody Background

CD2. also known as LFA-2 (lymphocyte function-associated antigen 2), is a 50-55 kDa cell surface glycoprotein belonging to the immunoglobulin (Ig) superfamily. It is primarily expressed on T lymphocytes, natural killer (NK) cells, and thymocytes. Discovered in the early 1980s, CD2 plays a critical role in mediating cell-cell interactions in the immune system. Its primary ligand is LFA-3 (CD58) in humans and CD48 in rodents, facilitating adhesion between T cells and antigen-presenting cells (APCs) or target cells. This interaction is essential for T-cell activation, cytotoxicity, and immune synapse formation.

CD2 antibodies, such as OKT11 and Leu-5b, have been widely used in research and diagnostics. They are employed to study T-cell development, activation, and adhesion mechanisms. In flow cytometry, anti-CD2 antibodies help identify and isolate T-cell subsets. Functionally, some CD2 antibodies act as agonists or antagonists, modulating T-cell responses by either enhancing or blocking CD2-ligand interactions. Early studies revealed that CD2 signaling can synergize with T-cell receptor (TCR) signals to amplify activation or, in certain contexts, induce anergy.

Therapeutically, CD2-targeting strategies have been explored in autoimmune diseases and transplantation. For example, alefacept, a fusion protein targeting CD2. was once used to treat psoriasis by depleting pathogenic T cells. Despite its reduced clinical use today, CD2 remains a key molecule in understanding adaptive immunity and developing immunomodulatory therapies. Research continues to explore its role in infectious diseases, cancer immunotherapy, and immune regulation.

       
關(guān)鍵字: CD2抗體;CD2;CD2 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤(pán)

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