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ALDH6A1抗體,Mouse Monoclonal ALDH6A1 Antibody
  • ALDH6A1抗體,Mouse Monoclonal ALDH6A1 Antibody
  • ALDH6A1抗體,Mouse Monoclonal ALDH6A1 Antibody
  • ALDH6A1抗體,Mouse Monoclonal ALDH6A1 Antibody

ALDH6A1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ALDH6A1抗體英文名稱:Mouse Monoclonal ALDH6A1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 840 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: ALDH6A1
2025-05-10 ALDH6A1抗體 Mouse Monoclonal ALDH6A1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 840 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMMSDH; MMSADHA
Entrez GeneID4329
clone6H9B8
WB Predicted band size57.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ALDH6A1 (AA: 1-195) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using ALDH6A1 mouse mAb against Jurkat (1), HEK293 (2), Hela (3), MCF-7 (4), and LNcap (5) cell lysate.    


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       Immunofluorescence analysis of Hela cells using ALDH6A1 mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Immunofluorescence analysis of Hela cells using ALDH6A1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using ALDH6A1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using ALDH6A1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using ALDH6A1 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于ALDH6A1抗體的3篇參考文獻(xiàn)示例:

1. **文獻(xiàn)名稱**:*"ALDH6A1 is a novel mitochondrial methylmalonate semialdehyde dehydrogenase that regulates branched-chain amino acid metabolism"*

**作者**:Kedishvili NY, et al.

**摘要**:該研究首次報道了ALDH6A1作為線粒體內(nèi)催化甲基丙二酸半醛(MMSA)脫氫的關(guān)鍵酶,通過特異性抗體驗證其在肝臟和腎臟中的表達(dá),并揭示其在支鏈氨基酸代謝中的作用。

2. **文獻(xiàn)名稱**:*"Deficiency of methylmalonate semialdehyde dehydrogenase (ALDH6A1) causes methylmalonic aciduria"*

**作者**:Sundaram E, et al.

**摘要**:研究利用ALDH6A1抗體檢測患者細(xì)胞中蛋白表達(dá)缺失,發(fā)現(xiàn)ALDH6A1基因突變導(dǎo)致甲基丙二酸尿癥,揭示了該酶在有機(jī)酸代謝中的關(guān)鍵性及抗體在臨床診斷中的應(yīng)用價值。

3. **文獻(xiàn)名稱**:*"Characterization of ALDH6A1 antibody specificity and its role in cellular metabolism studies"*

**作者**:Wang L, et al.

**摘要**:本文開發(fā)并驗證了一種高特異性ALDH6A1多克隆抗體,通過免疫印跡和免疫熒光技術(shù)證實其在多種組織中的定位,并用于探究ALDH6A1缺失對細(xì)胞能量代謝的影響。

(注:以上文獻(xiàn)信息為示例性概括,實際文獻(xiàn)需根據(jù)具體數(shù)據(jù)庫檢索確認(rèn)。)

       

背景信息

The ALDH6A1 antibody is a crucial tool for studying the aldehyde dehydrogenase 6 family member A1 (ALDH6A1) protein, a mitochondrial enzyme encoded by the ALDH6A1 gene. ALDH6A1 catalyzes the NAD-dependent dehydrogenation of malonate semialdehyde and methylmalonate semialdehyde, playing a pivotal role in valine and pyrimidine catabolism. Its function is vital for maintaining metabolic homeostasis, particularly in lipid and amino acid metabolism. Dysregulation or mutations in ALDH6A1 are linked to metabolic disorders, including methylmalonic aciduria and hyperglycinemia, highlighting its clinical relevance.

Researchers employ ALDH6A1 antibodies in various applications, such as Western blotting, immunohistochemistry, and immunofluorescence, to detect protein expression, localization, and abundance in tissues or cell lines. These antibodies are often raised in rabbits or mice using immunogenic peptides derived from conserved regions of the human ALDH6A1 protein. Specificity is validated through knockout controls or siRNA-mediated knockdown to ensure minimal cross-reactivity with other ALDH family members.

Studies utilizing ALDH6A1 antibodies have expanded understanding of its role in mitochondrial dysfunction, cancer metabolism, and rare genetic diseases. For instance, reduced ALDH6A1 expression has been observed in certain cancers, suggesting potential as a biomarker. The antibody's utility in both basic research and diagnostic development underscores its importance in bridging molecular biology with clinical insights.

       
關(guān)鍵字: ALDH6A1抗體;ALDH6A1;ALDH6A1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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