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PTPN6抗體,Mouse Monoclonal PTPN6 Antibody
  • PTPN6抗體,Mouse Monoclonal PTPN6 Antibody
  • PTPN6抗體,Mouse Monoclonal PTPN6 Antibody
  • PTPN6抗體,Mouse Monoclonal PTPN6 Antibody

PTPN6抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PTPN6抗體英文名稱:Mouse Monoclonal PTPN6 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 818 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): PTPN6
2025-05-10 PTPN6抗體 Mouse Monoclonal PTPN6 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 818 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
Entrez GeneID5777
clone2E9E4
WB Predicted band size67.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PTPN6 (AA: 243-541) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using PTPN6 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Raji cells using PTPN6 mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是3條關(guān)于PTPN6(SHP-1)抗體的參考文獻(xiàn)示例,包含文獻(xiàn)名稱、作者及摘要概括:

1. **"The role of SHP-1 tyrosine phosphatase in regulating immune cell signaling"**

- **作者**: Wu, J., & Zhang, L.

- **摘要**: 探討PTPN6(SHP-1)在免疫細(xì)胞(如T細(xì)胞、巨噬細(xì)胞)中的負(fù)調(diào)控作用,通過去磷酸化抑制JAK/STAT等信號通路,維持免疫穩(wěn)態(tài),并分析其抗體在自身免疫疾病研究中的應(yīng)用。

2. **"SHP-1 expression and function in hematologic malignancies"**

- **作者**: Lorenz, U., et al.

- **摘要**: 研究PTPN6在白血病等血液腫瘤中的表達(dá)異常,發(fā)現(xiàn)其功能缺失與致癌信號激活相關(guān),利用特異性抗體檢測SHP-1蛋白水平可為預(yù)后標(biāo)志物提供依據(jù)。

3. **"Autoantibodies against SHP-1 in systemic lupus erythematosus"**

- **作者**: An, H., et al.

- **摘要**: 報道系統(tǒng)性紅斑狼瘡(SLE)患者血清中存在抗PTPN6抗體,此類抗體通過干擾SHP-1的磷酸酶活性,導(dǎo)致B細(xì)胞過度活化,加劇自身免疫反應(yīng)。

4. **"Structural basis of SHP-1 activation by inhibitory receptors"**

- **作者**: Staal, F.J., et al.

- **摘要**: 通過晶體結(jié)構(gòu)分析揭示PTPN6與免疫抑制性受體(如KIR)的結(jié)合機(jī)制,并利用抗體阻斷實(shí)驗(yàn)驗(yàn)證其分子互作對下游信號通路的調(diào)控。

(注:上述文獻(xiàn)為示例,實(shí)際引用時需根據(jù)具體研究內(nèi)容核實(shí)文獻(xiàn)信息。)

       

背景信息

PTPN6. also known as SHP-1 (Src Homology 2 domain-containing Phosphatase-1), is a non-receptor protein tyrosine phosphatase encoded by the *PTPN6* gene. It plays a critical role in regulating cellular signaling by dephosphorylating target proteins, thereby modulating immune responses, cell growth, and differentiation. Primarily expressed in hematopoietic cells, SHP-1 acts as a negative regulator of signaling pathways in immune cells, including those mediated by cytokine receptors, antigen receptors, and receptor tyrosine kinases. Its dysfunction has been linked to autoimmune diseases, inflammatory disorders, and malignancies, such as leukemia and lymphoma.

PTPN6 antibodies are essential tools for studying the expression, localization, and function of SHP-1 in both physiological and pathological contexts. These antibodies enable detection of SHP-1 through techniques like Western blotting, immunohistochemistry, and flow cytometry. Researchers use them to investigate SHP-1's role in immune tolerance, tumor suppression, and its paradoxical pro-oncogenic effects in certain cancers. Specific PTPN6 antibodies can distinguish between inactive and active conformational states of the phosphatase, aiding in mechanistic studies of its regulation. Additionally, they are employed in diagnostic and therapeutic research to explore SHP-1-targeted interventions. High specificity and validation are crucial for these antibodies due to structural similarities among phosphatase family members. Understanding SHP-1's dual roles in disease continues to drive interest in developing precise research tools and potential therapies targeting this phosphatase.

       
關(guān)鍵字: PTPN6抗體;PTPN6;PTPN6 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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