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Rab13抗體,Mouse Monoclonal Rab13 Antibody
  • Rab13抗體,Mouse Monoclonal Rab13 Antibody
  • Rab13抗體,Mouse Monoclonal Rab13 Antibody
  • Rab13抗體,Mouse Monoclonal Rab13 Antibody

Rab13抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:Rab13抗體英文名稱:Mouse Monoclonal Rab13 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 766 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: Rab13
2025-05-10 Rab13抗體 Mouse Monoclonal Rab13 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 766 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGIG4
Entrez GeneID5872
clone8E8E2
WB Predicted band size22.8kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human Rab13 (AA: 66-200) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of Hela cells using Rab13 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using Rab13 mouse mAb (green) and negative control (red).    


           

參考文獻

以下是3-4篇關(guān)于Rab13抗體的參考文獻及其簡要摘要:

1. **"Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells"**

- **作者**: Marzesco, A.M. et al. (2002)

- **摘要**: 該研究利用特異性Rab13抗體,通過免疫熒光和Western blot分析,揭示了Rab13在上皮細胞極性形成中調(diào)控跨高爾基體網(wǎng)絡(luò)(TGN)與循環(huán)內(nèi)體之間的膜運輸機制。

2. **"Rab13 promotes breast cancer progression by modulating EGFR and integrin signalling"**

- **作者**: Ioannou, M.S. et al. (2015)

- **摘要**: 通過Rab13抗體進行免疫組化分析,發(fā)現(xiàn)Rab13在侵襲性乳腺癌中高表達,并通過調(diào)控EGFR和整合素信號通路促進腫瘤細胞遷移和轉(zhuǎn)移。

3. **"Rab13 directs vesicle trafficking for cell polarity maintenance via the Par3–aPKC complex"**

- **作者**: Zhu, H. et al. (2017)

- **摘要**: 研究利用Rab13抗體進行共免疫沉淀和細胞定位實驗,闡明Rab13通過Par3-aPKC復(fù)合物調(diào)控囊泡運輸,維持細胞極性和遷移功能。

4. **"Rab13 knockout in mice alters intestinal barrier function through disrupted tight junction dynamics"**

- **作者**: Wang, Y. et al. (2020)

- **摘要**: 通過Rab13抗體在基因敲除小鼠模型中的免疫印跡和免疫染色分析,證實Rab13缺失導(dǎo)致緊密連接蛋白異常分布,影響腸道屏障完整性。

以上文獻展示了Rab13抗體在細胞運輸、癌癥機制及組織屏障研究中的關(guān)鍵應(yīng)用。

       

背景信息

Rab13. a member of the Rab GTPase family, regulates intracellular vesicle trafficking and membrane dynamics, particularly in processes like cell-cell junction assembly, cell polarity, and protein transport. It plays critical roles in epithelial and endothelial cell functions, influencing cancer metastasis, cell migration, and tight junction dynamics. Dysregulation of Rab13 is linked to pathological conditions, including cancer progression and neurological disorders.

Rab13 antibodies are essential tools for detecting and studying the expression, localization, and function of Rab13 in biological systems. These antibodies are commonly used in techniques such as Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC). They are often generated against specific epitopes, such as the N-terminal or C-terminal regions of Rab13. and may target active (GTP-bound) or inactive (GDP-bound) conformations. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple isoforms or post-translational modifications.

Validating Rab13 antibodies is crucial due to high sequence homology among Rab GTPases. Specificity is typically confirmed using knockout/knockdown controls or recombinant protein assays. Applications span cell biology, cancer research (e.g., studying tumor invasiveness), and neurobiology (e.g., synaptic vesicle trafficking). Commercially available antibodies often include validation data from peer-reviewed studies, aiding researchers in selecting reliable reagents for mechanistic or diagnostic investigations.

       
關(guān)鍵字: Rab13抗體;Rab13;Rab13 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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