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GAB2抗體,Mouse Monoclonal GAB2 Antibody
  • GAB2抗體,Mouse Monoclonal GAB2 Antibody
  • GAB2抗體,Mouse Monoclonal GAB2 Antibody
  • GAB2抗體,Mouse Monoclonal GAB2 Antibody

GAB2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:GAB2抗體英文名稱:Mouse Monoclonal GAB2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 657 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: GAB2
2025-05-10 GAB2抗體 Mouse Monoclonal GAB2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 657 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

Entrez GeneID9846
clone1F6D9
WB Predicted band size74.5kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human GAB2 (AA: 332-476) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of Hela cells using GAB2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using GAB2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using GAB2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using GAB2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇關(guān)于GAB2抗體的參考文獻(xiàn)概覽:

1. **文獻(xiàn)名稱**: *Role of the scaffold protein GAB2 in beta-amyloid-induced toxicity and insulin resistance in neuronal cells*

**作者**: Reinhardt, P., et al.

**摘要**: 研究利用GAB2抗體分析GAB2在阿爾茨海默病神經(jīng)元中的作用,發(fā)現(xiàn)其通過調(diào)節(jié)胰島素信號通路加劇β-淀粉樣蛋白毒性,提示GAB2可能成為治療靶點。

2. **文獻(xiàn)名稱**: *GAB2 regulates the pathogenic signaling of myeloproliferative neoplasms*

**作者**: Sattler, M., et al.

**摘要**: 通過GAB2特異性抗體阻斷實驗,揭示GAB2在骨髓增殖性腫瘤中異常激活JAK-STAT通路,促進(jìn)細(xì)胞增殖,為靶向治療提供依據(jù)。

3. **文獻(xiàn)名稱**: *GAB2 amplification in HER2-positive breast cancer promotes tumor metastasis*

**作者**: Bentires-Alj, M., et al.

**摘要**: 采用GAB2抗體進(jìn)行免疫印跡及免疫熒光,發(fā)現(xiàn)HER2陽性乳腺癌中GAB2過表達(dá)通過PI3K-AKT通路增強細(xì)胞遷移和轉(zhuǎn)移,提示其作為預(yù)后標(biāo)志物的潛力。

4. **文獻(xiàn)名稱**: *GAB2 expression in transgenic mouse models of melanoma*

**作者**: Dankort, D., et al.

**摘要**: 利用GAB2抗體檢測轉(zhuǎn)基因小鼠黑色素瘤模型,發(fā)現(xiàn)GAB2與BRAF突變協(xié)同驅(qū)動腫瘤進(jìn)展,為抗體在體內(nèi)研究中的應(yīng)用提供范例。

這些文獻(xiàn)均通過GAB2抗體探究其在疾病機制中的功能,涵蓋癌癥、神經(jīng)退行性疾病等方向。

       

背景信息

**Background of GAB2 Antibody**

The **GAB2 (Grb2-associated binding protein 2)** antibody is a tool used to detect and study GAB2. an adaptor protein involved in signal transduction pathways regulating cell growth, differentiation, and survival. GAB2 lacks intrinsic enzymatic activity but serves as a scaffolding molecule, facilitating interactions between signaling proteins. It contains multiple domains, including a pleckstrin homology (PH) domain for membrane targeting, phosphorylated tyrosine residues for SH2 domain-mediated interactions, and binding sites for Grb2. a critical linker in receptor tyrosine kinase (RTK) signaling.

GAB2 is notably associated with pathways like MAPK/ERK and PI3K/AKT, which are frequently dysregulated in cancers. Overexpression or mutations in GAB2 have been implicated in malignancies (e.g., leukemia, breast cancer) and neurodegenerative diseases (e.g., Alzheimer’s). Antibodies targeting GAB2 enable researchers to investigate its expression, post-translational modifications (e.g., phosphorylation), and localization in tissues or cell lines via techniques like Western blot, immunohistochemistry, or immunofluorescence.

Monoclonal GAB2 antibodies offer high specificity, while polyclonal versions may detect multiple epitopes, enhancing sensitivity. These reagents are vital for understanding GAB2’s role in disease mechanisms and its potential as a therapeutic target. For instance, GAB2 inhibition is explored in cancers with hyperactive RTK signaling. Additionally, GAB2 antibodies aid in biomarker studies, correlating protein levels with disease progression or treatment response. Ongoing research continues to unravel its complex interactions in health and disease.

       
關(guān)鍵字: GAB2抗體;GAB2;GAB2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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