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ACLY抗體,Mouse Monoclonal ACLY Antibody
  • ACLY抗體,Mouse Monoclonal ACLY Antibody
  • ACLY抗體,Mouse Monoclonal ACLY Antibody
  • ACLY抗體,Mouse Monoclonal ACLY Antibody

ACLY抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ACLY抗體英文名稱:Mouse Monoclonal ACLY Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 570 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): ACLY
2025-05-10 ACLY抗體 Mouse Monoclonal ACLY Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 570 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat,Rabbit
IF咨詢技術(shù) Human,Mouse,Rat,Rabbit
IHC1/100 - 1/500 Human,Mouse,Rat,Rabbit
ICC1/50 - 1/500 Human,Mouse,Rat,Rabbit
FCM1/200 - 1/400 Human,Mouse,Rat,Rabbit
Elisa1/10000 Human,Mouse,Rat,Rabbit
   

產(chǎn)品詳情

AliasesACL; ATPCL; CLATP
Entrez GeneID47
clone5F8D11
WB Predicted band size125kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Monkey,Rabbit
ImmunogenPurified recombinant fragment of human ACLY (AA: 306-502 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using ACLY mouse mAb against HeLa (1), NIH3T3 (2), C6 (3), COS7 (4), and Raji (5) cell lysate.    


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       Western blot analysis using ACLY mouse mAb against PC-12(1)Raw264.7(2)NIH/3T3(3)NRK(4)C6(5)F9(6)COS-7(7)CHO3D10(8)cell lysate.    


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       Immunofluorescence analysis of HeLa cells using ACLY mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunofluorescence analysis of NIH/3T3 cells using ACLY mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Flow cytometric analysis of HeLa cells using ACLY mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using ACLY mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using ACLY mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse liver(A) Mouse kidney(B) using ACLY mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat liver(A) Rat kidney(B) using ACLY mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit liver(A) Rabbit kidney(B) using ACLY mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇涉及ACLY抗體的代表性文獻(xiàn)摘要(虛構(gòu)示例,僅供格式參考):

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1. **標(biāo)題**: *ACLY-mediated acetyl-CoA synthesis promotes hepatocellular carcinoma metastasis*

**作者**: Li, X. et al.

**摘要**: 研究通過Western blot和免疫組化(使用ACLY特異性抗體)發(fā)現(xiàn),ACLY在肝癌組織中高表達(dá),其介導(dǎo)的乙酰輔酶A生成通過調(diào)控上皮-間質(zhì)轉(zhuǎn)化促進(jìn)腫瘤轉(zhuǎn)移。抑制ACLY可降低體內(nèi)外轉(zhuǎn)移能力。

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2. **標(biāo)題**: *Antibody-based profiling of ACLY isoforms in Alzheimer's disease brain tissue*

**作者**: Smith, J.R. et al.

**摘要**: 利用ACLY多克隆抗體對阿爾茨海默病患者腦組織進(jìn)行蛋白質(zhì)分析,發(fā)現(xiàn)ACLY的磷酸化亞型在疾病進(jìn)展中顯著上調(diào),提示其與神經(jīng)元脂質(zhì)代謝紊亂相關(guān)。

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3. **標(biāo)題**: *Development of a high-affinity monoclonal ACLY antibody for metabolic studies*

**作者**: Tanaka, K. et al.

**摘要**: 報(bào)道一種新型ACLY單克隆抗體的開發(fā),驗(yàn)證其在流式細(xì)胞術(shù)和免疫沉淀中的特異性,并應(yīng)用于肥胖小鼠模型,揭示脂肪組織中ACLY的動(dòng)態(tài)表達(dá)變化。

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注:以上內(nèi)容為模擬生成,實(shí)際文獻(xiàn)需通過PubMed/Google Scholar檢索關(guān)鍵詞(如“ACLY antibody”、“ATP citrate lyase immunohistochemistry”)獲取。

       

背景信息

ACLY (ATP-citrate lyase) is a key metabolic enzyme that catalyzes the conversion of citrate and coenzyme A into acetyl-CoA and oxaloacetate, linking carbohydrate metabolism to lipid synthesis. Acetyl-CoA serves as a critical precursor for fatty acid and cholesterol biosynthesis, making ACLY essential in cellular energy homeostasis and proliferation. Dysregulation of ACLY is implicated in metabolic disorders, cancer, and cardiovascular diseases, as its overexpression enhances lipogenesis in tumors and contributes to hyperlipidemia.

ACLY antibodies are immunological tools designed to detect, quantify, or inhibit ACLY protein in research and diagnostic contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study ACLY expression patterns in tissues or cell lines, particularly in cancer metabolism studies. Specific antibodies may target distinct epitopes, including phosphorylated forms (e.g., at Ser455), to assess activation states regulated by signaling pathways like AKT.

Therapeutic interest in ACLY has surged due to its role as a druggable target; inhibitors like bempedoic acid (ETC-1002) are approved for lowering LDL cholesterol. ACLY antibodies thus also support drug development by validating target engagement or monitoring biomarker responses. Their applications span basic research on metabolic reprogramming, clinical biomarker discovery, and preclinical evaluation of metabolic therapies.

       
關(guān)鍵字: ACLY抗體;ACLY;ACLY Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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ACLY抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
¥1600.00
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北京索萊寶科技有限公司
2025-07-30
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VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
詢價(jià)
湖北艾普蒂生物工程有限公司
2024-02-21
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