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DKK3抗體,Mouse Monoclonal DKK3 Antibody
  • DKK3抗體,Mouse Monoclonal DKK3 Antibody
  • DKK3抗體,Mouse Monoclonal DKK3 Antibody
  • DKK3抗體,Mouse Monoclonal DKK3 Antibody

DKK3抗體

價(jià)格 詢(xún)價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):DKK3抗體英文名稱(chēng):Mouse Monoclonal DKK3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 569 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): DKK3
2025-05-10 DKK3抗體 Mouse Monoclonal DKK3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 569 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500-1/1000 Human,Mouse,Rat
IF咨詢(xún)技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢(xún) Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesRIG; REIC
Entrez GeneID27122
clone8A5C6
WB Predicted band size38.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Rabbit,Monkey
ImmunogenPurified recombinant fragment of human DKK3 (AA: 91-350 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using Desmin mouse mAb against PC-12(1),NIH/3T3(2),NRK(3),C2C12(4),C6(5), cell lysate.    


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       Flow cytometric analysis of Hela cells using DKK3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of C6 cells using DKK3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of NIH/3T3 cells using DKK3 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of COS7 cells using DKK3 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using DKK3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Mouse kidney using DKK3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rat kidney using DKK3 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded Rabbit kidney using DKK3 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于DKK3抗體的3篇參考文獻(xiàn)示例(注:以下內(nèi)容為示例,具體文獻(xiàn)需根據(jù)實(shí)際研究調(diào)整):

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1. **文獻(xiàn)名稱(chēng)**: *"DKK3 Neutralizing Antibody Improves Renal Fibrosis by Blocking Wnt/β-Catenin Signaling"*

**作者**: Miao, H., Zhang, Y., & Li, X.

**摘要**: 該研究開(kāi)發(fā)了一種靶向DKK3的中和抗體,并在小鼠慢性腎病模型中驗(yàn)證其療效。結(jié)果顯示,抗體治療顯著抑制了腎間質(zhì)纖維化,機(jī)制與阻斷Wnt/β-catenin信號(hào)通路的異常激活相關(guān),提示DKK3抗體在抗纖維化治療中的潛力。

2. **文獻(xiàn)名稱(chēng)**: *"A Humanized Anti-DKK3 Antibody Enhances Chemotherapy Efficacy in Glioblastoma"*

**作者**: Foroni, C., Rossi, M., & Pellegatta, S.

**摘要**: 研究利用人源化DKK3抗體聯(lián)合替莫唑胺治療膠質(zhì)母細(xì)胞瘤。實(shí)驗(yàn)表明,抗體通過(guò)抑制DKK3介導(dǎo)的腫瘤干細(xì)胞信號(hào)通路,顯著增強(qiáng)化療藥物敏感性,并延長(zhǎng)小鼠生存期。

3. **文獻(xiàn)名稱(chēng)**: *"Development of a DKK3-Specific ELISA for Early Detection of Hepatocellular Carcinoma"*

**作者**: Wang, L., Chen, T., & Liu, S.

**摘要**: 研究基于DKK3單克隆抗體開(kāi)發(fā)了高靈敏度ELISA檢測(cè)方法,用于肝癌早期篩查。臨床樣本分析顯示,血清DKK3水平在肝癌患者中顯著升高,且與腫瘤分期正相關(guān),驗(yàn)證了其作為新型診斷標(biāo)志物的價(jià)值。

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如需具體文獻(xiàn),建議通過(guò)PubMed或Google Scholar檢索關(guān)鍵詞“DKK3 antibody therapeutic”或“DKK3 biomarker”,并篩選近年研究。

       

背景信息

DKK3 (Dickkopf-related protein 3) is a secreted glycoprotein belonging to the Dickkopf family, known for its role in modulating Wnt signaling pathways. Unlike DKK1 and DKK2. which primarily inhibit canonical Wnt/β-catenin signaling, DKK3 exhibits a more complex regulatory mechanism, interacting with diverse receptors like Kremen and LRP5/6. though its precise molecular targets remain under investigation. It is broadly expressed in adult tissues, including the kidneys, heart, and nervous system, and plays critical roles in embryonic development, tissue homeostasis, and cellular differentiation.

Dysregulation of DKK3 is implicated in multiple pathological conditions. In cancer, DKK3 often acts as a tumor suppressor, with reduced expression observed in malignancies like prostate, lung, and colorectal cancers. Conversely, it may promote fibrosis in chronic kidney disease and cardiac remodeling. DKK3 antibodies, both monoclonal and polyclonal, are vital tools for studying these processes. They enable detection of DKK3 expression via immunohistochemistry, Western blotting, or ELISA, aiding in biomarker research and therapeutic exploration. Recent studies also explore DKK3 antibodies as potential therapeutics to modulate Wnt-related pathways in diseases such as fibrosis or osteoporosis.

Despite progress, challenges persist in understanding context-specific DKK3 functions and optimizing antibody-based interventions. Ongoing research aims to clarify its dual roles in different tissues and diseases, highlighting its therapeutic and diagnostic potential.

       
關(guān)鍵字: DKK3抗體;DKK3;DKK3 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶(hù)的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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DKK3抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱(chēng) 價(jià)格   公司名稱(chēng) 報(bào)價(jià)日期
¥1138
VIP3年
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2025-08-01
詢(xún)價(jià)
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-03
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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