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SOX9抗體,Mouse Monoclonal SOX9 Antibody
  • SOX9抗體,Mouse Monoclonal SOX9 Antibody
  • SOX9抗體,Mouse Monoclonal SOX9 Antibody
  • SOX9抗體,Mouse Monoclonal SOX9 Antibody

SOX9抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SOX9抗體英文名稱:Mouse Monoclonal SOX9 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 466 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): SOX9
2025-05-10 SOX9抗體 Mouse Monoclonal SOX9 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 466 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCMD1; SRA1; CMPD1
Entrez GeneID6662
clone1B11
WB Predicted band size56kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SOX9 expressed in E. Coli.  
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using SOX9 mouse mAb against Lovo (1) and SW620 (2) cell lysate.    


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       Immunofluorescence analysis of Hela cells using SOX9 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


           

參考文獻(xiàn)

以下是3-4條關(guān)于 **SOX9抗體** 的參考文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱**:*"A monoclonal antibody against Sox9 reveals its role in cartilage development"*

**作者**:Bi, W., et al.

**摘要**:該研究開發(fā)了一種特異性識(shí)別SOX9蛋白的單克隆抗體,并驗(yàn)證其在胚胎發(fā)育中軟骨形成的關(guān)鍵作用。通過(guò)免疫組化和Western blot分析,揭示了SOX9在軟骨細(xì)胞分化中的動(dòng)態(tài)表達(dá)模式。

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2. **文獻(xiàn)名稱**:*"Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest"*

**作者**:Mori-Akiyama, Y., et al.

**摘要**:利用SOX9抗體進(jìn)行免疫熒光和染色質(zhì)免疫沉淀(ChIP),研究發(fā)現(xiàn)SOX9在顱神經(jīng)嵴細(xì)胞向軟骨細(xì)胞譜系分化中起決定性作用,并調(diào)控下游靶基因(如Col2a1)的表達(dá)。

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3. **文獻(xiàn)名稱**:*"SOX9 is a prostate cancer tumor suppressor and master regulator of lineage plasticity"*

**作者**:Thomsen, M.K., et al.

**摘要**:通過(guò)免疫組化分析前列腺癌組織,發(fā)現(xiàn)SOX9表達(dá)缺失與腫瘤進(jìn)展相關(guān)。研究利用特異性抗體證實(shí)SOX9通過(guò)抑制上皮-間質(zhì)轉(zhuǎn)化(EMT)維持細(xì)胞分化,具有腫瘤抑制功能。

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4. **文獻(xiàn)名稱**:*"Validation of a polyclonal anti-SOX9 antibody for functional studies in zebrafish"*

**作者**:Yan, Y.L., et al.

**摘要**:該文獻(xiàn)驗(yàn)證了一種兔源多克隆SOX9抗體的跨物種適用性(包括斑馬魚和小鼠),證明其可用于原位雜交和蛋白定位,并揭示了SOX9在脊椎動(dòng)物性別決定和器官發(fā)育中的保守性。

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這些文獻(xiàn)涵蓋了SOX9抗體在基礎(chǔ)研究(如發(fā)育生物學(xué))和疾病模型(如癌癥)中的應(yīng)用,涉及抗體開發(fā)、驗(yàn)證及功能機(jī)制解析。

       

背景信息

SOX9 antibodies are essential tools in biomedical research for detecting and analyzing the SOX9 protein, a transcription factor belonging to the SOX (SRY-related HMG-box) family. SOX9 plays pivotal roles in embryonic development, particularly in chondrogenesis, sex determination, and neural crest cell differentiation. It regulates gene expression by binding to DNA through its HMG domain, influencing cell fate and tissue morphogenesis. Mutations in the SOX9 gene are linked to congenital disorders like campomelic dysplasia, characterized by skeletal malformations and sex reversal. In cancer, SOX9 exhibits context-dependent roles, acting as an oncogene in some malignancies (e.g., prostate cancer, glioblastoma) or a tumor suppressor in others (e.g., skin squamous cell carcinoma).

SOX9 antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study protein expression, localization, and function. These antibodies help identify SOX9 in tissue sections, cell lines, or animal models, aiding research on developmental biology, disease mechanisms, and regenerative medicine. Validation of SOX9 antibodies is critical, as specificity can vary between clones and applications. Commercial antibodies are often raised against epitopes within the N-terminal transactivation domain or the C-terminal region. Researchers rely on SOX9 antibodies to explore its regulatory networks, interactions with signaling pathways (e.g., Wnt/β-catenin, TGF-β), and therapeutic targeting potential in developmental disorders and cancers.

       
關(guān)鍵字: SOX9抗體;SOX9;SOX9 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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SOX9抗體相關(guān)廠家報(bào)價(jià)

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湖北艾普蒂生物工程有限公司
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