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BID抗體,Mouse Monoclonal BID Antibody
  • BID抗體,Mouse Monoclonal BID Antibody
  • BID抗體,Mouse Monoclonal BID Antibody
  • BID抗體,Mouse Monoclonal BID Antibody

BID抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BID抗體英文名稱:Mouse Monoclonal BID Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 396 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: BID
2025-05-09 BID抗體 Mouse Monoclonal BID Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 396 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesFP497; MGC15319; MGC42355; BID
Entrez GeneID637
clone3C5
WB Predicted band size22kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant full length protein of human BID expressed in E. Coli
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using BID mouse mAb against Hela (1), A431 (2), Jurkat (3), A549 (4), HepG2 (5), and HEK293 (6) cell lysate.    


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       Immunofluorescence analysis of Hela cells using BID mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of Hela cells using BID mouse mAb (green) and negative control (purple).    


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       Immunohistochemical analysis of paraffin-embedded human prostate tissues (left) and tonsil tissues (right) using BID mouse mAb with DAB staining.    


           

參考文獻

以下是關(guān)于BID抗體的3篇代表性文獻,涵蓋其功能機制及應(yīng)用研究:

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1. **文獻名稱**:**"BID: A Novel BH3 Domain-Only Death Agonist"**

**作者**:Wang, K., Yin, X. M., Chao, D. T., Milliman, C. L., & Korsmeyer, S. J.

**摘要**:該研究首次鑒定BID為僅含BH3結(jié)構(gòu)域的促凋亡蛋白,揭示了其被caspase-8切割激活為截短形式tBID的過程,并證明tBID通過誘導(dǎo)線粒體細胞色素c釋放放大凋亡信號,連接死亡受體與線粒體凋亡通路。

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2. **文獻名稱**:**"Cleavage of BID by Caspase 8 Mediates Mitochondrial Damage in the Fas Pathway of Apoptosis"**

**作者**:Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X.

**摘要**:通過Western blot(使用BID特異性抗體)和功能實驗,證實Fas激活后caspase-8切割BID生成tBID,后者易位至線粒體并與BAX/BAK相互作用,導(dǎo)致線粒體外膜通透性增加,從而驅(qū)動細胞凋亡。

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3. **文獻名稱**:**"Proapoptotic BID regulates hematopoietic stem cell homeostasis and tumor suppression"**

**作者**:Zinkel, S. S., Hurov, K. E., Ong, C., Abtahi, F. M., Gross, A., & Korsmeyer, S. J.

**摘要**:利用BID基因敲除小鼠及BID抗體檢測,發(fā)現(xiàn)BID缺失導(dǎo)致造血干細胞穩(wěn)態(tài)失調(diào)和淋巴瘤易感性增加,表明BID在維持正常凋亡及抑制腫瘤發(fā)生中的關(guān)鍵作用。

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這些研究揭示了BID在凋亡信號轉(zhuǎn)導(dǎo)中的核心地位,并展示了相關(guān)抗體在機制探索和疾病模型中的應(yīng)用。如需更多文獻或細節(jié),可進一步限定研究領(lǐng)域或?qū)嶒灧椒ā?/p>

       

背景信息

BID (BH3-interacting domain death agonist) is a pro-apoptotic protein belonging to the Bcl-2 family, critical in regulating mitochondrial-dependent apoptosis. It exists as an inactive cytosolic monomer (full-length BID) until activated by proteolytic cleavage (e.g., by caspase-8 or granzyme B), generating truncated BID (tBID). This activated form translocates to mitochondria, where it induces oligomerization of BAX/BAK, triggering outer mitochondrial membrane permeabilization (MOMP) and cytochrome c release, ultimately activating caspases for apoptosis execution. BID serves as a molecular bridge connecting extrinsic (death receptor) and intrinsic (mitochondrial) apoptosis pathways. Dysregulation of BID is implicated in cancer, neurodegenerative diseases, and liver injury. Anti-BID antibodies are essential tools for detecting BID expression, activation status (via cleavage-specific epitopes), and subcellular localization in research. They enable studies on apoptosis mechanisms, drug responses, and disease pathogenesis. Commercial antibodies typically target specific regions (e.g., BH3 domain or cleavage sites) and require validation in applications like Western blotting, immunohistochemistry, and flow cytometry. Proper controls are crucial due to potential cross-reactivity with other Bcl-2 family proteins.
       
關(guān)鍵字: BID抗體;BID;BID Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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