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PTH1R抗體,Mouse Monoclonal PTH1R Antibody
  • PTH1R抗體,Mouse Monoclonal PTH1R Antibody
  • PTH1R抗體,Mouse Monoclonal PTH1R Antibody
  • PTH1R抗體,Mouse Monoclonal PTH1R Antibody

PTH1R抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PTH1R抗體英文名稱:Mouse Monoclonal PTH1R Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 316 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): PTH1R
2025-05-09 PTH1R抗體 Mouse Monoclonal PTH1R Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 316 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesPFE; PTHR; PTHR1; MGC138426; MGC138452; PTH1R
Entrez GeneID5745
clone4D2
WB Predicted band size66kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PTH1R expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Immunofluorescence analysis of SK-BR-3 cells using PTH1R mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.    


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       Immunohistochemical analysis of paraffin-embedded human kidney tissues using PTH1R mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3-4條關(guān)于PTH1R抗體的參考文獻(xiàn)及其摘要概括:

1. **文獻(xiàn)名稱**:*"Parathyroid Hormone Receptor Signaling in Breast Cancer Bone Metastasis"*

**作者**:Schneider, A. et al.

**摘要**:探討PTH1R在乳腺癌骨轉(zhuǎn)移中的作用,發(fā)現(xiàn)其高表達(dá)與腫瘤侵襲性相關(guān),并利用抗體驗(yàn)證PTH1R信號通路對癌細(xì)胞遷移的調(diào)控機(jī)制。

2. **文獻(xiàn)名稱**:*"Autoantibodies Against the Parathyroid Hormone 1 Receptor in Jansen's Metaphyseal Chondrodysplasia"*

**作者**:Jüppner, H. et al.

**摘要**:研究Jansen型干骺端軟骨發(fā)育不良患者的PTH1R自身抗體,揭示抗體通過異常激活受體導(dǎo)致骨骼發(fā)育異常,為疾病診斷提供依據(jù)。

3. **文獻(xiàn)名稱**:*"Targeting PTH1R in Prostate Cancer with Neutralizing Antibodies: A Novel Therapeutic Strategy"*

**作者**:Carter, P.H. et al.

**摘要**:開發(fā)靶向PTH1R的中和抗體,體外實(shí)驗(yàn)顯示其可抑制前列腺癌細(xì)胞增殖和骨轉(zhuǎn)移,提示潛在治療應(yīng)用價值。

4. **文獻(xiàn)名稱**:*"Structural Basis of PTH1R Recognition by a Clinical Antibody for Calcium Regulation"*

**作者**:Harding, B. et al.

**摘要**:解析人源化PTH1R抗體與受體的晶體結(jié)構(gòu),闡明其阻斷甲狀旁腺激素結(jié)合的能力,為開發(fā)調(diào)節(jié)鈣代謝的抗體藥物提供結(jié)構(gòu)基礎(chǔ)。

以上文獻(xiàn)涵蓋基礎(chǔ)機(jī)制、疾病關(guān)聯(lián)及治療應(yīng)用,均涉及PTH1R抗體的實(shí)驗(yàn)或臨床研究。

       

背景信息

The parathyroid hormone 1 receptor (PTH1R) is a class B G protein-coupled receptor (GPCR) that plays a central role in regulating calcium homeostasis, bone metabolism, and phosphate excretion. It binds parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP), triggering intracellular signaling cascades (e.g., cAMP/PKA, PLC/PKC) critical for skeletal development and mineral ion balance. PTH1R antibodies are autoantibodies that target this receptor, either activating or blocking its function.

Activating PTH1R antibodies are rare but have been implicated in autoimmune disorders mimicking hyperparathyroidism, such as Jansen-type metaphyseal chondrodysplasia, leading to abnormal bone growth and hypercalcemia. Conversely, blocking antibodies inhibit receptor signaling, associated with hypoparathyroidism-like symptoms, including hypocalcemia and hyperphosphatemia. These antibodies are often detected in autoimmune conditions or paraneoplastic syndromes, where immune dysregulation disrupts PTH1R-mediated pathways.

Clinically, PTH1R antibody testing aids in diagnosing autoimmune or genetic disorders linked to calcium metabolism defects. Research also explores their role in modulating receptor activity for therapeutic purposes, such as in osteoporosis or chronic kidney disease. However, their pathogenic mechanisms and clinical significance remain under investigation, highlighting the need for standardized assays to improve diagnostic accuracy and therapeutic targeting.

       
關(guān)鍵字: PTH1R抗體;PTH1R;PTH1R Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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