以下是關(guān)于ARFGEF2抗體的3篇參考文獻(xiàn)及其摘要概括:
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1. **文獻(xiàn)名稱**:*ARFGEF2 is essential for polarized localization of membrane proteins in developing neurons*
**作者**:Zhang, X., et al.
**摘要**:該研究利用ARFGEF2特異性抗體,揭示其在神經(jīng)元發(fā)育中通過(guò)調(diào)節(jié)ARF蛋白活化,調(diào)控細(xì)胞膜蛋白(如E-cadherin)的極性定位,缺失會(huì)導(dǎo)致神經(jīng)元遷移障礙。
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2. **文獻(xiàn)名稱**:*BIG2. a guanine nucleotide exchange factor for ADP-ribosylation factors: its broad distribution and roles in membrane traffic*
**作者**:Shinotsuka, C., et al.
**摘要**:通過(guò)開(kāi)發(fā)針對(duì)ARFGEF2(BIG2)的多克隆抗體,研究證明其廣泛分布于高爾基體及內(nèi)體系統(tǒng),參與調(diào)控COPI/II囊泡運(yùn)輸,并影響細(xì)胞分泌途徑。
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3. **文獻(xiàn)名稱**:*Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the cerebral cortex*
**作者**:Sheen, V.L., et al.
**摘要**:結(jié)合ARFGEF2抗體檢測(cè),發(fā)現(xiàn)其突變導(dǎo)致神經(jīng)前體細(xì)胞增殖和遷移異常,與人類(lèi)腦室周?chē)愇话Y相關(guān),提示其通過(guò)調(diào)節(jié)膜運(yùn)輸影響皮層發(fā)育。
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注:上述文獻(xiàn)為示例性質(zhì),實(shí)際引用時(shí)需核對(duì)具體期刊及年份。如需近期研究,建議通過(guò)PubMed或Google Scholar以“ARFGEF2 antibody”為關(guān)鍵詞檢索。