+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P04213(SYT2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

Synaptotagmin-2 (SYT2) is a calcium-sensing synaptic vesicle protein predominantly expressed in presynaptic terminals, particularly at neuromuscular junctions and central nervous system synapses. As a member of the synaptotagmin family, SYT2 plays a critical role in synchronous neurotransmitter release by triggering vesicle fusion through calcium-dependent interactions with SNARE complexes and membrane phospholipids. Its two C2 domains (C2A and C2B) mediate calcium-dependent membrane binding, a mechanism essential for fast synaptic transmission.

SYT2 antibodies are widely used in neuroscience research to study synaptic function, synaptic vesicle dynamics, and disorders linked to neurotransmission defects. Mutations in the SYT2 gene are associated with congenital neuromuscular diseases, including presynaptic congenital myasthenic syndrome (CMS), characterized by muscle weakness and fatigability. SYT2-specific antibodies also serve as biomarkers in autoimmune disorders like Lambert-Eaton myasthenic syndrome (LEMS), where autoantibodies disrupt presynaptic voltage-gated calcium channels.

In experimental applications, SYT2 antibodies are employed for immunohistochemistry, Western blotting, and immunofluorescence to map SYT2 expression patterns in neuronal tissues or model organisms. Recent studies explore SYT2's role in neurodegenerative diseases and its potential as a therapeutic target. Commercial SYT2 antibodies are typically validated in human, rodent, and zebrafish models, reflecting its evolutionary conservation and functional importance across species.