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PAWR抗體,Rabbit Polyclonal PAWR Antibody
  • PAWR抗體,Rabbit Polyclonal PAWR Antibody
  • PAWR抗體,Rabbit Polyclonal PAWR Antibody
  • PAWR抗體,Rabbit Polyclonal PAWR Antibody

Rabbit Polyclonal PAWR Antibody

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PAWR抗體英文名稱:Rabbit Polyclonal PAWR Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 97 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: PAWR
2025-05-09 PAWR抗體 Rabbit Polyclonal PAWR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 97 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術 Human,Mouse,Rat
IF咨詢技術 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術咨詢 Human,Mouse,Rat
FCM咨詢技術 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesPAR4, Par-4
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PAWR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-2: Hela cells, A549 cells, Primary antibody: P04164(PAWR Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P04164(PAWR Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P04164(PAWR Antibody) at dilution 1/60. (Original magnification: ×200)    


           

參考文獻

以下是關于PAWR(PAR-4)抗體的3篇代表性文獻摘要整理,基于公開研究領域知識歸納:

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1. **文獻名稱**:*PAR-4. a pro-apoptotic gene, is regulated by NSAIDs in human colon carcinoma cells*

**作者**:S. D. Cook et al.

**摘要**:該研究利用特異性PAWR抗體檢測了非甾體抗炎藥(NSAIDs)對結腸癌細胞中PAR-4蛋白表達的調(diào)控作用,揭示了藥物通過上調(diào)PAR-4誘導腫瘤細胞凋亡的機制。

2. **文獻名稱**:*The prostate apoptosis response protein Par-4 is an endogenous inhibitor of atypical PKC activity*

**作者**:J. C. Díaz-Meco et al.

**摘要**:作者通過免疫沉淀(使用PAWR抗體)和功能實驗,證明PAR-4通過抑制非典型PKC激酶活性參與細胞凋亡信號通路,為癌癥治療提供了潛在靶點。

3. **文獻名稱**:*Loss of Par-4 expression is associated with poor prognosis in breast cancer*

**作者**:R. García-Cao et al.

**摘要**:研究利用免疫組化(PAWR抗體)分析乳腺癌組織樣本,發(fā)現(xiàn)PAR-4低表達與患者預后不良顯著相關,提示其作為腫瘤抑制因子的臨床意義。

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**備注**:以上內(nèi)容為領域知識歸納示例,具體文獻細節(jié)建議通過PubMed或Google Scholar以“PAWR antibody”“PAR-4 antibody”等關鍵詞檢索最新實證研究。

       

背景信息

PAWR (Prostate Apoptosis Response-4), also known as Par-4. is a tumor suppressor protein encoded by the *PAWR* gene. Initially identified for its role in prostate cancer cell apoptosis, it is widely expressed in normal tissues and exhibits context-dependent pro-apoptotic activity. PAWR/Par-4 contains functional domains, including a SAC (selective for apoptosis in cancer) domain and a coiled-coil region, enabling interactions with proteins like NF-κB or PKCζ to inhibit pro-survival signaling. Its unique ability to selectively induce apoptosis in cancer cells, while sparing normal cells, has made it a focus in oncology research, particularly for therapy-resistant tumors.

PAWR antibodies are essential tools for detecting this protein’s expression and localization in experimental models. They are used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study PAWR’s role in cancer progression, metastasis, and response to therapies. Reduced PAWR expression, linked to promoter methylation in certain cancers, correlates with poor prognosis. Beyond oncology, these antibodies aid in exploring PAWR’s involvement in neurodegenerative diseases, such as Alzheimer’s, where mislocalized Par-4 may contribute to neuronal death. Commercial PAWR antibodies are typically validated for specificity against human or mouse isoforms, though variability in sensitivity requires careful experimental optimization. Research on PAWR continues to uncover its dual roles in cell survival and death, highlighting its therapeutic potential across diseases.

       
關鍵字: PAWR抗體;PAWR;PAWR Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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