鏈接：https://www.abinscience.cn/product/34/15095.html

名稱：Anti-Ganglioside GM2 Antibody (E1)

貨號：YP081013

寄主物種：Mouse

形式：Liquid

純度：>95% as determined by SDS-PAGE.

克隆性：Monoclonal

同種型：IgG2a, kappa

應(yīng)用：ELISA, IHC

靶點：Ganglioside GM2, Monosialoganglioside GM2, GM2 lipid

用途范圍：僅用于科研

儲存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

產(chǎn)品介紹：Ganglioside GM2 是一種人腫瘤抗原，主要存在于人類腫瘤細胞及胎兒腦組織中。Ganglioside GM2 屬于唾液酸化糖鞘脂，參與細胞信號轉(zhuǎn)導(dǎo)、黏附、運動等過程。Ganglioside GM2 異常表達和積累與腫瘤、神經(jīng)退行性病變相關(guān)。Ganglioside GM2 通過與整合素 β1 受體直接結(jié)合，激活 FAK/Src/Erk-MAPK 信號通路并誘導(dǎo)肌動蛋白細胞骨架重塑，從而促進腫瘤細胞遷移和侵襲。abinScience產(chǎn)品具有親和力高，靈敏度高，特異性好，穩(wěn)定性強等優(yōu)勢。

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郵箱：info@abinscience.com

參考文獻：

Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions. PMID: 37877564
GM2 ganglioside and pyramidal neuron dendritogenesis. PMID: 8786814
Biochemical Correction of GM2 Ganglioside Accumulation in AB-Variant GM2 Gangliosidosis. PMID: 37298170
Disordered testosterone transport in mice lacking the ganglioside GM2/GD2 synthase gene. PMID: 36999634
Regulation of GM2 ganglioside metabolism in cultured cells. PMID: 3549015
Ganglioside GM2: a potential biomarker for cholangiocarcinoma. PMID: 32692591
Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs. PMID: 31097363
Cranial multineuritis associated with anti-GM2 ganglioside antibodies after SARS-CoV-2 infection. PMID: 37045672
Antibodies to GM2 ganglioside in neurological disorders. PMID: 12705785
Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage. PMID: 31852956
Serum anti-GM2 and anti-GalNAc-GD1a ganglioside IgG antibodies are biomarkers for immune-mediated polyneuropathies in cats. PMID: 36573790
GM2 ganglioside accumulation causes neuroinflammation and behavioral alterations in a mouse model of early onset Tay-Sachs disease. PMID: 32951593
Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. PMID: 27066976
Ganglioside vaccines with emphasis on GM2. PMID: 9865678
Ganglioside GM2 N-acetyl-beta-D-galactosaminidase and asialo GM2 (GA2) N-acetyl-beta-D-galactosaminidase; studies in human skin fibroblasts. PMID: 13950
Abnormally accumulated GM2 ganglioside contributes to skeletal deformity in Tay-Sachs mice. PMID: 39514043
Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity. PMID: 36131294
Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells. PMID: 10073593
GM2 ganglioside in fetal Tay-Sachs disease brain cultures: a model system for the disease. PMID: 953690
Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. PMID: 18272501
Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease. PMID: 22205997
Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside. PMID: 30389374
Ganglioside GM2 is substrate for a sialidase in MDCK cells. PMID: 9645488
Both ganglioside GM2 and cholesterol in the cell membrane are essential for Bombyx mori cypovirus cell entry. PMID: 30031014
Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients. PMID: 3472242
Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies. PMID: 17196574
GM2 ganglioside lysosomal storage disease in cats with beta-hexosaminidase deficiency. PMID: 404709
Incorporation and metabolism of ganglioside GM2 in skin fibroblasts from normal and GM2 gangliosidosis subjects. PMID: 3922757
Autoimmunity to the GM2-1 islet ganglioside before and at the onset of type I diabetes. PMID: 8772721
Monoclonal antibody directed to a Hanganutziu-Deicher active ganglioside, GM2 (NeuGc). PMID: 2449247
N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice. PMID: 18207611
Anti-GM2 ganglioside antibodies are a biomarker for acute canine polyradiculoneuritis. PMID: 23521648
[GM2 ganglioside activator protein deficiency]. PMID: 9645092

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