
ZT-12-037-01 NEW
Price | $30 | $68 | $117 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-07-27 |
Product Details
Product Name: ZT-12-037-01 | CAS No.: 2328073-61-4 |
Purity: 99.56% | Supply Ability: 10g |
Release date: 2025/07/27 |
Product Introduction
Bioactivity
Name | ZT-12-037-01 |
Description | Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively). |
Animal Research | ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3. |
In vitro | ZT-12-037-01 significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation. |
In vivo | ZT-12-037-01 as a specific STK19-targeted inhibitor and it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vivo. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Solubility Information | DMSO : 41 mg/mL (106.36 mM), Sonication is recommended. |
Keywords | ZT-12-037-01 | ZT1203701 | ZT 12 037 01 | STK19 | SerineProtease | Serine Protease | Ras | Inhibitor | inhibit |
Inhibitors Related | Nafamostat mesylate | PMSF | AEBSF hydrochloride | Ketoconazole | Salirasib | RMC-6236 | (S)-(-)-Perillyl alcohol | Ceritinib | Aprotinin | CASIN | 4-Aminobenzamidine dihydrochloride | Benzamidine hydrochloride |
Related Compound Libraries | Highly Selective Inhibitor Library | Ferroptosis Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Glutamine Metabolism Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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