Vismodegib N-Oxide；2248170-87-6

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E-mail: anna@molcoo.com.

• Product Information

• Product Number: V043002

• English Name: Vismodegib N-Oxide

• English Alias: 2-(2-chloro-5-(2-chloro-4-(methylsulfonyl)benzamido)phenyl)pyridine 1-oxide

• CAS Number: 2248170-87-6

• Molecular Formula: C??H??Cl?N?O?S

• Molecular Weight: 437.30

• Advantages

• As the N-oxide impurity of Vismodegib, this compound has the following advantages:
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• Well-defined and distinct structure: The unique N-oxidized pyridine ring structure is significantly different from the parent Vismodegib, containing functional groups such as chlorine atoms, methylsulfonyl groups, and oxidized pyridine rings, which can be accurately identified by chromatographic and mass spectrometric techniques, providing a clear marker for impurity detection;

• High stability and specificity: The oxidized pyridine ring structure is stable under conventional storage conditions and directly related to the metabolic pathway of Vismodegib, which can specifically reflect the degradation trend of the drug in oxidative environments, improving the accuracy of impurity tracing;

• Outstanding value as a detection standard: As a key impurity from the oxidative degradation of Vismodegib, its structural characteristics provide an exclusive standard for detection methods such as HPLC and LC-MS, enabling effective differentiation between the parent drug and other degradation products and improving quantitative precision.

• Applications

• Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Vismodegib N-Oxide in Vismodegib APIs and formulations, ensuring product purity meets pharmacopoeia and regulatory requirements;

• Stability studies: Monitoring the generation of this impurity under light, high temperature, and oxidative conditions to evaluate the storage stability of Vismodegib formulations and support the development of appropriate packaging and storage conditions;

• Metabolic pathway research: As a potential product of Vismodegib's in vitro and in vivo oxidative metabolism, it is used to explore the drug's metabolic mechanisms and analyze the impact of N-oxidation on drug activity and toxicity.

• Background Description

• Vismodegib is a Hedgehog signaling pathway inhibitor used in the treatment of tumors such as basal cell carcinoma. During storage or in vivo metabolism, the pyridine ring may undergo N-oxidation to form impurities like Vismodegib N-Oxide. The presence of this impurity may affect the drug's stability, bioavailability, or potential toxicity. Thus, researching and controlling it is a key part of ensuring the quality and clinical safety of Vismodegib products.

• Research Status

• Current research focuses on:
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• Optimization of detection methods: Using UPLC-MS/MS technology to optimize separation conditions based on the polarity difference of the oxidized pyridine ring, achieving trace detection of this impurity (detection limit up to ppb level);

• Analysis of degradation mechanisms: Clarifying the formation kinetics of this impurity through accelerated experiments simulating different oxidative conditions (e.g., hydrogen peroxide treatment) to elucidate the oxidative degradation pathway of Vismodegib;

• Toxicological evaluation: Comparing the Hedgehog signaling pathway inhibitory activity of this impurity and Vismodegib through in vitro cell experiments to assess its potential pharmacological interference or toxic effects;

• Establishment of quality standards: Combining data from multiple batches of samples to provide a scientific basis for the limit standards of this impurity in Vismodegib formulations, improving the quality control system.

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com