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Postion:Product Catalog >Vismodegib Impurity 11
Vismodegib Impurity 11
  • Vismodegib Impurity 11
  • Vismodegib Impurity 11
  • Vismodegib Impurity 11
  • Vismodegib Impurity 11
  • Vismodegib Impurity 11

Vismodegib Impurity 11 NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-17

Product Details

Product Name: Vismodegib Impurity 11 CAS No.: 1195072-86-6
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/17
Molecular formula: C19H15ClN2O3S

Vismodegib Impurity 11;1195072-86-6

Article illustration

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
.

Product Information

  • Product Number: V043011

  • English Name: Vismodegib Impurity 11

  • English Alias: N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

  • CAS Number: 1195072-86-6

  • Molecular Formula: C??H??ClN?O?S

  • Molecular Weight: 386.85

Advantages

As an ortho-dechlorinated impurity of Vismodegib, this compound has the following advantages:


  • Well-defined and distinct structure: Compared with the parent Vismodegib, it only lacks the chlorine atom at the ortho-position (2nd position) of the benzoyl group, while the rest of the structure (4th position chlorine atom, methylsulfonyl group, pyridine ring, amide bond) remains intact. It can be accurately distinguished by techniques such as HPLC and LC-MS, providing a specific marker for impurity detection;

  • High stability and homology: Sharing the core skeleton of Vismodegib with similar chemical stability, it directly reflects incomplete chlorination of benzoyl chloride raw materials in synthesis, improving the accuracy of process tracing;

  • High detection sensitivity: The conjugated structure of methylsulfonyl group and benzene ring has strong absorption in the UV region (around 254nm), enabling trace analysis via HPLC-UV, reducing detection costs and enhancing method applicability.

Applications

  • Pharmaceutical quality control: Used as an impurity reference standard to identify and quantify Impurity 11 in Vismodegib APIs, ensuring residual impurities from incomplete chlorination of benzoyl chloride meet quality standards;

  • Synthesis process optimization: Reducing impurity formation by monitoring its content and optimizing chlorination conditions of benzoyl chloride (e.g., chlorine gas dosage) to improve ortho-chlorine introduction efficiency;

  • Structure-activity relationship research: Used to study the impact of ortho-chlorine removal on Vismodegib's biological activity, providing reference for drug structure-activity relationship analysis.

Research Status

Current research focuses on:


  • Detection method optimization: Using UPLC-MS/MS technology to optimize mass spectrometry selected ion pairs based on the difference in chlorine atom count (one less than Vismodegib), achieving trace detection of this impurity (detection limits up to ppb level);

  • Chlorination process improvement: Developing catalytic systems (e.g., iron(III) chloride) to enhance ortho-selective chlorination of benzoyl chloride, reducing the formation of this impurity;

  • Binding affinity studies: Comparing the binding affinity of this impurity and Vismodegib to SMO protein via surface plasmon resonance (SPR) to evaluate the impact of ortho-chlorine removal on target interaction;

  • Quality standard integration: Incorporating this impurity into Vismodegib's impurity control strategy based on stability data, ensuring long-term product quality consistency.

Advantages

As an ortho-dechlorinated impurity of Vismodegib, this compound has the following advantages:


  • Well-defined and distinct structure: Compared with the parent Vismodegib, it only lacks the chlorine atom at the ortho-position (2nd position) of the benzoyl group, while the rest of the structure (4th position chlorine atom, methylsulfonyl group, pyridine ring, amide bond) remains intact. It can be accurately distinguished by techniques such as HPLC and LC-MS, providing a specific marker for impurity detection;

  • High stability and homology: Sharing the core skeleton of Vismodegib with similar chemical stability, it directly reflects incomplete chlorination of benzoyl chloride raw materials in synthesis, improving the accuracy of process tracing;

  • High detection sensitivity: The conjugated structure of methylsulfonyl group and benzene ring has strong absorption in the UV region (around 254nm), enabling trace analysis via HPLC-UV, reducing detection costs and enhancing method applicability.

Applications


This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com








Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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