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Postion:Product Catalog >TL13-112
TL13-112
  • TL13-112

TL13-112 NEW

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Package 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-19

Product Details

Product Name: TL13-112 CAS No.: 2229037-19-6
Supply Ability: 10g Release date: 2025/07/19

Product Introduction

Bioactivity

NameTL13-112
DescriptionTL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
In vitroTL13-112 binds to cereblon(IC50 of 2.4 uM). in H3122 cell and Karpas 299, TL13-112 (0.01 μM-1 μM; 16 hours)?is selective for degradation of ALK(DC50s of 10 nM and 40 nM, respectively). ALK degradation acts at 4 hours of treatment in H3122 cells and at 8 hours of treatment in Karpas 299 cells. The maximum degradation achieves at 16 hours in both cell lines. .TL13-112 (0.01 μM-1 μM; 16 hours) inhibits PTK2, ALK, FER, RPS6KA1 and Aurora A expression as a dose-dependent manner in H3122, Karpas 299, and Kelly cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
KeywordsTL13-112 | TL-13-112 | TL13112 | TL13 112 | Cereblon
Inhibitors RelatedARV-393 HCl | Gefitinib-based PROTAC 3 | ACBI1 | ARV-471 | CCT367766 | dBET6 | dBET1 | Dbet57 | ARV-825 | β-NF-JQ1 | C004019 | GMB-475

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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