NO 711 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-17 |
Product Details
| Product Name: NO 711 | CAS No.: 159094-94-7 |
| Purity: 99.83% | Supply Ability: 10g |
| Release date: 2025/06/17 |
Product Introduction
Bioactivity
| Name | NO 711 |
| Description | NO 711（NNC-711 free acid） is a potent and selective inhibitor of GABA transporter 1 (GAT-1), which increases GABAergic transmission, enhances non-rapid eye movement sleep, and prevents and treats paclitaxel-induced neuropathic pain. |
| In vitro | Treatment of microglia with NO 711 (1 μM, 0-15 minutes) significantly reduced Na+-dependent GABA uptake. [2] |
| In vivo | Methods: 12-, 18-, and 25-day-old rat pups with implanted electrodes were used. Epileptic foci were induced by local application of dithiothreitol methyl iodide (BMI) via an implanted cannula over the sensorimotor cortical area, and cortical afterepileptic discharges (ADs) were induced by low-frequency stimulation (8 Hz) of the same cortical area. Epileptic foci were formed after pretreatment with NO 711 (1 or 10 mg/kg, i.p.), and epileptic ADs were induced in a second experimental series. NNC-711 was then applied at the same dose, and stimulation was repeated. Results: NO 711 did not block the formation of epileptogenic foci, but it significantly inhibited the spontaneous transition of interictal focal to ictal activity in all age groups. In 18- and 25-day-old rats, the intensity of movements accompanying sensorimotor cortical stimulation was smaller under the influence of NNC-711. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | Urethane | p-Hydroxybenzaldehyde | Penicillin G sodium salt | Valproic Acid | Halothane | Chlorothymol | Gabapentin | Riluzole | (-)-α-Pinene | Methionine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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