NNC 05-711 NEW
| Price | $63 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-01 |
Product Details
| Product Name: NNC 05-711 | CAS No.: 145645-62-1 |
| Purity: 99.92% | Supply Ability: 10g |
| Release date: 2025/06/01 |
Product Introduction
Bioactivity
| Name | NNC 05-711 |
| Description | NNC 05-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1), which inhibits GABA reuptake and thereby increases GABA levels in the synaptic gap, exerting anticonvulsant and analgesic effects. |
| In vitro | Treatment of microglia with NNC 05-711 (1 μM, 0-15 minutes) significantly reduced Na+-dependent GABA uptake in microglia. [1] |
| In vivo | Methods: NNC 05-711 (50, 100, 200 μg/10 μL, intrathecal injection, once a day) was used to treat rats with chronic sciatic nerve constriction injury (CCI) and its analgesic effect was observed. Results: NNC 05-711 exerted an effective analgesic effect in the CCI rat model. Compared with the CCI + saline group, the paw withdrawal threshold (WT) and paw withdrawal latency (WL) values ??increased after 1 day. [3] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 2 mg/mL (5.17 mM), Sonication is recommended. DMSO : 80 mg/mL (206.79 mM), Sonication is recommended. |
| Keywords | NO-711-hydrochloride | NNC-711 | NNC711 | NNC 711 |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | Urethane | p-Hydroxybenzaldehyde | Penicillin G sodium salt | Valproic Acid | Halothane | Chlorothymol | Gabapentin | Riluzole | (-)-α-Pinene | Methionine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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