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Postion:Product Catalog >Monophosphoryl lipid A
Monophosphoryl lipid A
  • Monophosphoryl lipid A

Monophosphoryl lipid A NEW

Price $1110
Package 1mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-16

Product Details

Product Name: Monophosphoryl lipid A CAS No.: 1246298-63-4
Supply Ability: 10g Release date: 2025/07/16

Product Introduction

Bioactivity

NameMonophosphoryl lipid A
DescriptionMonophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development.
In vitroMonophosphoryl lipid A, at a concentration of 100 μg/ml for 2 hours, induces NF-κB activation and modulates TLR2 in dendritic cells, as evidenced by Western Blot Analysis. The same compound, ranging from 5 to 100 μg/ml over 24 hours, stimulates IL-12 production in human dendritic cells. Furthermore, increasing Monophosphoryl lipid A levels from 0.1 to 1 μg results in a higher percentage of matured bone marrow-derived dendritic cells (BMDCs). It also enhances cell surface markers on dendritic cells and boosts T cell responses, including the upregulation of calcium mobilization in activated CD4 T cells.
In vivoThe synthesized Monophosphoryl lipid A activates antigen-presenting cells (APCs) and amplifies the production of Th1- and Th2-specific immune responses in mice[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
KeywordsMonophosphoryl lipid A

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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