Product Details
| Product Name:
JI069 |
CAS No.:
850019-35-1 |
| Purity:
98.01% |
Supply Ability:
10g |
| Release date:
2025/07/25 |
Product Introduction
Bioactivity
| Name | JI069 |
| Description | JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1. |
| In vitro | In HEK293T cells and primary T cells, JI069 (1-10 μM) suppressed STAT3 activation as efficiently as other STATs, including STAT1, STAT5, and STAT6. JI069 effectively suppressed Th1, Th2, and Th17 differentiation while strongly promoting Treg differentiation.[1] |
| In vivo | JI069 (25mg/kg weight; i.p.; 6-week-old DBA/1J mice) suppressed symptoms of collagen-induced arthritis (CIA) model in mice and inhibited the cytokine production from T cells as well as the STAT3 phosphorylation of synovial cells.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25 mg/mL (64.56 mM), Sonication is recommended.
|
| Keywords | WAY354189 | WAY 354189 | STAT | JI-069 | JI069 | JI 069 | JAK |
| Inhibitors Related | Delgocitinib | HODHBt | Ruxolitinib | Nifuroxazide | Tofacitinib Citrate | Niclosamide | Ruxolitinib phosphate | Balsalazide disodium dihydrate | CASIN | Diosgenin | Niclosamide olamine | Artesunate |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | JAK-STAT Compound Library | Stem Cell Differentiation Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States