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Postion:Product Catalog >ALK5 Inhibitor II (hydrochloride)
ALK5 Inhibitor II (hydrochloride)
  • ALK5 Inhibitor II (hydrochloride)

ALK5 Inhibitor II (hydrochloride) NEW

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Package 1mg 5mg 10mg
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Supply Ability: 10g
Update Time: 2025-07-16

Product Details

Product Name: ALK5 Inhibitor II (hydrochloride) CAS No.: 2319939-07-4
Supply Ability: 10g Release date: 2025/07/16

Product Introduction

Bioactivity

NameALK5 Inhibitor II (hydrochloride)
DescriptionALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.
In vitroIn vitro: ALK5 inhibitor II was identified as a cell-permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5. ALK5 inhibitor II showed less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. In addition, when cocrystallized with ALK5, ALK5 inhibitor II was found to be able to bind in the ATP site with the 1,5-naphthyridine N5 interacting with the backbone NH of His-283 [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationEthanol : ≤0.5 mg/mL, Sonication is recommended.
KeywordsALK5 Inhibitor II (hydrochloride) | ALK5 Inhibitor II | ALK-5 Inhibitor II (hydrochloride)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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