Product Information

Product Number: D024010

English Name: Diltiazem N-Oxide

English Alias: 2-((2S,3S)-3-acetoxy-2-(4-methoxyphenyl)-4-oxo-3,4-dihydrobenzo[b][1,4]thiazepin-5(2H)-yl)-N,N-dimethylethanamine oxide

CAS Number: None

Molecular Formula: C??H??N?O?S

Molecular Weight: 430.52

Advantages

Well-defined structure and high stability, which can be used to analyze the by-product formation mechanism of amine oxidation reactions during diltiazem synthesis or storage, optimizing processes to control N-oxide impurity generation;

Serving as a reference standard containing sulfur-nitrogen heterocycles and amine oxide structures, providing a standard substance for detecting amine oxide impurities in drugs, and helping to evaluate drug safety (amine oxides may affect drug metabolic pathways);

Helping study the impact of oxidation modification on drug physicochemical properties (such as polarity, water solubility) and toxicological characteristics to provide a scientific basis for formulating impurity control strategies.

Applications

Drug Development: Used as an impurity reference standard to identify and quantify N-oxide impurities in diltiazem preparations, evaluating the purity of APIs and formulations;

Quality Control: Acting as a standard substance to validate the sensitivity of detection methods (e.g., HPLC or LC-MS), ensuring N-oxide impurity content meets ICH guideline requirements during production;

Metabolism Research: Assisting in studying the oxidative metabolic pathway of diltiazem in vivo to provide references for pharmacokinetic research.

Background Description

Research Status

Synthesis Methods: Developing high-purity synthesis processes for Diltiazem N-Oxide, solving the challenge of poor stability of amine oxide compounds to meet the needs of toxicological research and quality control;

Detection Technologies: Establishing trace detection methods for N-oxide impurities (detection limits reach ppb level) using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and other technologies;

Toxicological Evaluation: Studying the potential mutagenicity of this impurity through in vitro Ames tests and animal models;

Process Control: Analyzing the inducements of oxidation reactions (such as oxygen exposure, catalyst residues) to optimize the synthesis route or storage conditions to reduce the generation of N-oxide impurities.