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Postion:Product Catalog >Organic Chemistry>Heterocyclic Compounds>CMS121
CMS121
  • CMS121
  • CMS121

CMS121 NEW

Price $9 $6 $3
Package 1KG 10KG 25KG
Min. Order: 0.1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2025-06-21

Product Details

Product Name: CMS121 CAS No.: 1353224-53-9
Min. Order: 0.1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2025/06/21
Lead time: In stock, ready for shipment Packaging: 1kg,5kg,25kgs,200kgs;bulk
Delivery: By express, by air, by sea Origin: Manufacturer, advantage product
COA, MSDS: Available, contact us for details Note: Hot sales


CMS121

Modify Date: 2024-01-02 20:42:47

Article illustration
CMS121 structure
Common NameCMS121
CAS Number1353224-53-9Molecular Weight321.37
DensityN/ABoiling PointN/A
Molecular FormulaC20H19NO3Melting PointN/A
MSDSN/AFlash PointN/A








PurityQuantityBudgetInquiry

 Use of CMS121


CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].

 Names

NameCMS-121

 CMS121 Biological Activity

DescriptionCMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].
Related Catalog
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase
Research Areas >> Neurological Disease
Target

Acetyl-CoA carboxylase 1 (ACC1)[1]

In VitroCMS-121 (1 μM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1]. Western Blot Analysis[1] Cell Line: HT22 cells Concentration: 1 μM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79.
In VivoCMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1]. Animal Model: Female SAMP8 mice (9 months old)[1] Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain.
References

[1]. Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866.

[2]. Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89.

[3]. Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13.

 Chemical & Physical Properties

Molecular FormulaC20H19NO3
Molecular Weight321.37
Storage condition-20°C



Company Profile


    Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.


Our Company

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Our Advantage

Quality control

Based on industry norms, customer requirements, and internal quality objectives, we establish clear quality standards. By monitoring the production process in real-time, we ensure that every step conforms to the predetermined quality standards.

Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.


Technological innovation

Our technological innovation is reflected in the development of new materials that are at the leading edge of the industry. These materials not only possess higher performance and lower costs but also enable sustainable use within an environmentally friendly production process.


Competitiveness

Based on rich experience in material development and production, we have established a more scientific cost control system. By ensuring product quality, and through refined management and continuous process optimization, we offer more competitive prices.


Word of mouth

Adhering to the principle of customer first, customer first, and honest service, we have established long-term business relationships with customers and are deeply welcomed and trusted by them.


Rich experience

Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.

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Safe and fast delivery

We will arrange shipment of spot products as soon as we receive payment.

Customized products are determined based on the synthesis time of different products.

 

Excellent pre-sales and after-sales service

Pre sales:

We are committed to providing the most favorable quotes and detailed information about our products and company.

After-sale service:

We assist buyers in customs clearance by providing necessary documents and information.

If there is any dispute over product quality, we are committed to providing the best solution.


Our packaging and shipping

? Packaging: 

1kg/bag or bottle, 25kg/drum, 50kg/drum, 200L/drum, 1T/bag or IBC drum, standard export packaging or packaging required by customers.

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Shipping

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? Delivery:

Within 7 days after receiving your payment

 

Contact information

For more details, pls contact us freely.

Name: Elin

Email: jiuyitime@fdachem.com


 Sincerely hope to establish friendly business relationships with new and old customers, and jointly create a beautiful future for the fine chemical industry!



Company Profile Introduction

Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions. With our agile custom synthesis capabilities and responsive supply chain system, our products have gained widespread adoption across Asian markets including Japan, South Korea, Singapore, and Malaysia, while also expanding deeply into Europe and the Americas. We have forged long-term strategic partnerships with numerous leading global enterprises in the sector. "Driving value through technology and earning trust through service" is our core mission. Looking ahead, we will continue to focus on technological breakthroughs and green innovation in new materials, collaborating with partners to build a high-quality industrial ecosystem and provide globally competitive solutions with greater foresight.

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