
J-147 NEW
Price | $9 | $6 | $3 |
Package | 1KG | 10KG | 25KG |
Min. Order: | 0.1KG |
Supply Ability: | g-kg-tons, free sample is available |
Update Time: | 2025-06-21 |
Product Details
Product Name: J-147 | CAS No.: 1146963-51-0 |
Min. Order: 0.1KG | Purity: 99% |
Supply Ability: g-kg-tons, free sample is available | Release date: 2025/06/21 |
Lead time: In stock, ready for shipment | Packaging: 1kg,5kg,25kgs,200kgs;bulk |
Delivery: By express, by air, by sea | Origin: Manufacturer, advantage product |
COA, MSDS: Available, contact us for details | Note: Hot sales |
J-147
![]() J-147 structure | Common Name | J-147 | ||
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CAS Number | 1146963-51-0 | Molecular Weight | 350.335 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 412.8±55.0 °C at 760 mmHg | |
Molecular Formula | C18H17F3N2O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 203.5±31.5 °C | |
Purity | Quantity | Budget | Inquiry |
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Use of J-147J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 – 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism). |
Name | j 147 |
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Synonym | More Synonyms |
Description | J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 – 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism). |
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Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease |
References | [1]. Lapchak PA, et al. J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeToxTM Safety and Genotoxicity Analysis. J Neurol Neurophysiol. 2013 Aug;4(3). pii: 158. |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 412.8±55.0 °C at 760 mmHg |
Molecular Formula | C18H17F3N2O2 |
Molecular Weight | 350.335 |
Flash Point | 203.5±31.5 °C |
Exact Mass | 350.124207 |
PSA | 41.90000 |
LogP | 5.61 |
Appearance of Characters | light yellow solid |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.515 |
Storage condition | -20℃ |
![]() 1-(2,4-dimethyl... CAS#:391646-35-8 ![]() Trifluoroacetic... CAS#:407-25-0 ~85% ![]() J-147 CAS#:1146963-51-0 |
Literature: Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 2 p. 524 - 527 |
![]() m-Anisaldehyde CAS#:591-31-1 ~% ![]() J-147 CAS#:1146963-51-0 |
Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 2 p. 524 - 527 |
Precursor 3 | |
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Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
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Based on industry norms, customer requirements, and internal quality objectives, we establish clear quality standards. By monitoring the production process in real-time, we ensure that every step conforms to the predetermined quality standards.
Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.
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Our technological innovation is reflected in the development of new materials that are at the leading edge of the industry. These materials not only possess higher performance and lower costs but also enable sustainable use within an environmentally friendly production process.
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Based on rich experience in material development and production, we have established a more scientific cost control system. By ensuring product quality, and through refined management and continuous process optimization, we offer more competitive prices.
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Name: Elin
Email: jiuyitime@fdachem.com
Sincerely hope to establish friendly business relationships with new and old customers, and jointly create a beautiful future for the fine chemical industry!
Company Profile Introduction
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