Product Details
| Product Name:
Cirsimaritin |
CAS No.:
6601-62-3 |
| Purity:
99.59% |
Supply Ability:
10g |
| Release date:
2025/06/26 |
Product Introduction
Bioactivity
| Name | Cirsimaritin |
| Description | Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. |
| In vitro | Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt [1]. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner [2]. |
| In vivo | Cirsimaritin significantly reduces anxiety in mice. The high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg)[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Soluble
|
| Keywords | γ-Aminobutyric acid Receptor | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAA | GABA Receptor | Cirsimaritin |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | Valproic Acid | Halothane | Chlorothymol | Piperazine citrate | (-)-α-Pinene | Methionine |
| Related Compound Libraries | Polyphenolic Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$7.00/1KG |
VIP8Y
|
Career Henan Chemical Co
|
2019-08-31 |
United States