Chlortalidone Impurity; 5543-24-8

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E-mail: anna@molcoo.com

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• Chlortalidone Impurity 1

• Product Information

• Product Code: C138001

• English Name: Chlortalidone Impurity 1

• English Alias: 2-(2-chlorobenzoyl)benzoic acid

• CAS No.：5543-24-8

• Molecular Formula: C??H?ClO?

• Molecular Weight: 260.67

• Advantages

• High Purity: HPLC ≥99.0%, confirmed by NMR (1H, 13C) and HRMS, ensuring accuracy for impurity analysis.

• Stability: Shelf life of 24 months at 2-8℃ in dark, with <0.5% degradation in DMSO within 1 month.

• Regulatory Compliance: Meets ICH/FDA standards for pharmaceutical impurity control.

• Applications

• Quality Control: Detects Impurity 1 in Chlortalidone API via HPLC/LC-MS, ensuring ≤0.1% limit (ICH Q3A).

• Process Optimization: Monitors chlorobenzoylation side reactions during synthesis to adjust reaction conditions.

• Method Validation: Serves as a reference standard for analytical method development.

• Background Description

• Chlortalidone, a thiazide-like diuretic, may generate this impurity from incomplete condensation or chlorination side reactions. Strict impurity control is essential for drug safety and efficacy.

• Research Status

• Detection: UPLC-MS/MS with C18 column (1.7μm) achieves LOD of 0.01 ng/mL.

• Formation: Arises from excess 2-chlorobenzoyl chloride; optimized stoichiometry reduces content by 70%.

• Toxicity: In vitro studies show low cytotoxicity; ongoing safety evaluations pending.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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