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Postion:Product Catalog >Chlortalidone Impurity
Chlortalidone Impurity
  • Chlortalidone Impurity
  • Chlortalidone Impurity
  • Chlortalidone Impurity
  • Chlortalidone Impurity
  • Chlortalidone Impurity

Chlortalidone Impurity NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-31

Product Details

Product Name: Chlortalidone Impurity CAS No.: 955-16-8
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/31

Chlortalidone Impurity; 955-16-8

Article illustration

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

  • .

  • Chlortalidone Impurity 3

  • Product Information

  • Product Code: C138003

  • English Name: Chlortalidone Impurity 3

  • English Alias: 5-phenylisobenzofuran-1,3-dione

  • CAS No.:955-16-8

  • Molecular Formula: C??H?O?

  • Molecular Weight: 224.21

  • Advantages

  • Purity Assurance: HPLC ≥99.5%, confirmed by IR and melting point analysis.

  • Stability: Shelf life of 36 months at room temperature, with <0.1% degradation in ethyl acetate.

  • Regulatory Compliance: Meets ICH Q3A for organic impurities in diuretics.

  • Applications

  • Residual Impurity Control: Detects benzofuranone in Chlortalidone via GC-MS.

  • Process Optimization: Monitors decarboxylation side reactions during synthesis.

  • Method Validation: Validates GC methods for volatile impurities.

  • Background Description

  • This impurity originates from thermal degradation or cyclization of benzoic acid intermediates. It requires control due to potential genotoxicity concerns.
  • Research Status

  • Detection: GC-MS with DB-5 column; LOD: 1 ppm.

  • Formation: Induced by high-temperature reaction steps; reducing reaction temperature lowers content by 80%.

  • Toxicity: Ames test shows no mutagenicity; further genotoxicity studies ongoing.

NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com


NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 


Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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